{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:58:55Z","timestamp":1783630735222,"version":"3.55.0"},"reference-count":94,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Lamiaceae family, encompassing diverse plant species, holds significant value in food, medicine, and cosmetics. Within this family, <jats:italic>Pentapleura subulifera<\/jats:italic> and <jats:italic>Cyclotrichium glabrescens<\/jats:italic>, relatively unexplored species, were investigated for their chemical composition, antioxidant capacity, and enzyme\u2010inhibiting effects. The chemical composition of hexane, methanolic, and aqueous extracts from <jats:italic>P.\u2005subulifera<\/jats:italic> and <jats:italic>C.\u2005glabrescens<\/jats:italic> were analyzed using LC\u2010ESI\u2010MS\/MS and the non\u2010polar hexane fraction was investigated via GC\u2010MS. The antioxidant potential of the extracts was determined through radical scavenging, reducing power and metal chelating assays. Additionally, inhibitory activity against six enzymes \u2013 acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, and glucosidase \u2013 was examined. The aqueous extract of <jats:italic>P.\u2005subulifera<\/jats:italic> and the methanolic extract of <jats:italic>C.\u2005glabrescens<\/jats:italic> exhibited elevated phenolic content at 129.47\u2005mg gallic acid equivalent (GAE)\/g and 55.97\u2005mg GAE\/g, respectively. Chemical profiling of the constituents of the two plant species resulted in the identification of a total of twenty compounds. The majority of which belonged to flavonoids and quinic acid derivatives, primarily concentrated in the methanol and aqueous extracts. Among all antioxidant assays, the aqueous extracts of <jats:italic>P.\u2005subulifera<\/jats:italic> demonstrated superior antioxidant activity, with the highest recorded activity of 404.93\u2005mg trolox equivalent (TE)\/g in the cupric reducing antioxidant capacity (CUPRAC) test. Meanwhile, the hexane extract of <jats:italic>C.\u2005glabrescens<\/jats:italic> exhibited the highest AChE inhibitory activity at 2.71\u2005mg galanthamine equivalent (GALAE)\/g, followed by the methanol extract of <jats:italic>P.\u2005subulifera<\/jats:italic> at 2.41\u2005mg GALAE\/g. These findings unequivocally establish the notable antioxidant and enzyme inhibitory activity of <jats:italic>P.\u2005subulifera<\/jats:italic> and <jats:italic>C.\u2005glabrescens<\/jats:italic> extracts, underscoring their potential as a source of valuable natural antioxidants.<\/jats:p>","DOI":"10.1002\/cbdv.202301651","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T20:44:05Z","timestamp":1701204245000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Assessing the Chemical Composition, Antioxidant and enzyme Inhibitory Effects of <i>Pentapleura subulifera<\/i> and <i>Cyclotrichium glabrescens<\/i> Extracts"],"prefix":"10.1002","volume":"21","author":[{"given":"Nilofar","family":"Nilofar","sequence":"first","affiliation":[{"name":"Physiology and Biochemistry Laboratory Department of Biology Science Faculty Selcuk University  Konya Turkey"},{"name":"Department of Pharmacy, Botanic Garden \u201cGiardino dei Semplici\u201d Universit\u00e0 degli Studi \u201cGabriele d'Annunzio\u201d  via dei Vestini 31 66100 Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Physiology and Biochemistry Laboratory Department of Biology Science Faculty Selcuk University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikail","family":"Acar","sequence":"additional","affiliation":[{"name":"Munzur University Department of Plant and Animal Production Tunceli Vocational School of Higher Education  Tunceli 62000 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhakim","family":"Bouyayha","sequence":"additional","affiliation":[{"name":"Laboratory of Human Pathologies Biology Faculty of Sciences Mohammed V University in Rabat  Rabat 10106 Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aalilou","family":"Youssra","sequence":"additional","affiliation":[{"name":"Laboratory of Human Pathologies Biology Faculty of Sciences Mohammed V University in Rabat  Rabat 10106 Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omayma","family":"Eldahshan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain Shams University, Abbassia  11566 Cairo Egypt"},{"name":"Center of Drug Discovery Research and Development Ain Shams University, Abbassia  Cairo 11566 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa","family":"Fayez","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain Shams University, Abbassia  11566 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouran","family":"Fahmy","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain Shams University, Abbassia  11566 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"158","volume":"3","author":"Eldahshan O.","year":"2009","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867328999201123194510"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201500139"},{"key":"e_1_2_9_4_1","volume":"38","author":"Eldahshan O.","year":"2018","journal-title":"Taeckholmia"},{"key":"e_1_2_9_5_1","volume":"2","author":"Yani A.","year":"2018","journal-title":"Taeckholmia"},{"key":"e_1_2_9_6_1","first-page":"82","volume":"1","author":"Venkateshappa S.","year":"2013","journal-title":"AIJRFANS"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3923\/rjmp.2012.203.213"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13129"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.30848\/PJB2022-3(19)"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27249029"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871523016666170502121419"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113338"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1108\/NFS-11-2011-0131"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0257-7941.150777"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2022.114818"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2010.01.016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2005.9698876"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/tax.591013"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2013.813208"},{"key":"e_1_2_9_20_1","first-page":"841","volume":"72","author":"Karab\u00f6rkl\u00fc S.","year":"2019","journal-title":"C.\u2005R. Acad. Bulg. Sci"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2004.08.024"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14177"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880200802435903"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-007-0250-7"},{"key":"e_1_2_9_25_1","volume-title":"\u2032Chapter\u20054 - Phytochemistry, Chemotaxonomy, Ethnopharmacology, and Nutraceutics of Lamiaceae\u2032","author":"Frezza C."},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100775"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1527-4238"},{"key":"e_1_2_9_28_1","first-page":"316","volume":"13","author":"Guzel A.","year":"2017","journal-title":"Pharmacogn. Mag."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c00837"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15060663"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2788"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3238561"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.12295"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2016.11.055"},{"key":"e_1_2_9_35_1","first-page":"23","volume":"3","author":"Ahmed R.","year":"2019","journal-title":"J. Adv. Pharm. Res."},{"key":"e_1_2_9_36_1","volume":"31","author":"Krasteva I.","year":"2008","journal-title":"Quim. Nova"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.951"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.05.077"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160818396"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.200990088"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.58.9.0015"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0231(19991215)13:23<2399::AID-RCM805>3.0.CO;2-N"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.2954"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-020-02547-2"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2016.11.031"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.08.057"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2017.06.008"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2014.04.036"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO00055G"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/00387010.2019.1682013"},{"key":"e_1_2_9_51_1","volume":"10","author":"Mosad G.","year":"2018","journal-title":"Pharmacog. Res."},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2014.12.035"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2019.108614"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.463704"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-021-03525-y"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942910701567364"},{"key":"e_1_2_9_57_1","first-page":"316","volume":"13","author":"Guzel A.","year":"2017","journal-title":"Pharmacogn. Mag."},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1831"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12128"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2008.00649.x"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.70902"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24729"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.12.009"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2013.10.003"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2013.02.008"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9010076"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.07.117"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394598-3.00003-4"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf990146l"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2022.102417"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2004.03.014"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.47.1.185"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO00220C"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13007-019-0487-8"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2019.108905"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2011.10.016"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527315666160321110607"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(95)90117-5"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1177\/11795735211029113"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8120608"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111377"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics3040036"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-5362.245965"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12152785"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12136561"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA10044G"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2017.01.016"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13950"},{"key":"e_1_2_9_89_1","first-page":"70","volume":"08","author":"Momeni J.","year":"2016","journal-title":"Nat. Sci."},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.5344\/ajev.1977.28.1.49"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2017.03.005"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.04.012"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2018-0216"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2018.11.018"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202301651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T23:27:11Z","timestamp":1741735631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202301651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":94,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/cbdv.202301651"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202301651","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,13]]},"assertion":[{"value":"2023-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202301651"}}