{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T17:59:18Z","timestamp":1775671158330,"version":"3.50.1"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this research, the total phenolic and flavonoid amounts, phenolic compositions, <jats:italic>in\u2005vitro<\/jats:italic> antioxidant, antibacterial and antidiabetic properties of the methanol extracts obtained from <jats:italic>Scabiosa<\/jats:italic> L. (<jats:italic>Caprifoliaceae<\/jats:italic>) species distributed in the flora of T\u00fcrkiye were investigated using chemometric methods. For this purpose, principal component (PCA) and agglomerative hierarchical clustering analysis were performed as chemometric methods. Chlorogenic acid, quinic acid and cyranoside were determined in the extracts. According to chemometric analysis, <jats:italic>S. columbaria<\/jats:italic> subsp. <jats:italic>ochroleuca<\/jats:italic> var. <jats:italic>ochroleuca<\/jats:italic> and <jats:italic>S. triniifolia<\/jats:italic> species were found to be valuable in terms of methanol extract yields, total phenolic and flavonoid contents, antioxidant and antidiabetic activities while <jats:italic>S. columbaria<\/jats:italic> subsp. <jats:italic>ochroleuca<\/jats:italic> var. <jats:italic>webbiana<\/jats:italic> species were found to be valuable in terms of phenolic composition. The methanol extracts of <jats:italic>Scabiosa<\/jats:italic> species showed high antioxidant activity, with high phenolic and flavonoid contents. Among the tested 13 bacteria, <jats:italic>Scabiosa<\/jats:italic> extracts showed only low activity against <jats:italic>Klebsiella pneumoniae<\/jats:italic>, <jats:italic>Streptococcus pneumoniae<\/jats:italic> and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>. The extracts showed high \u03b1\u2010amylase and \u03b1\u2010glucosidase inhibitory activity. The results show that <jats:italic>Scabiosa<\/jats:italic> methanol extracts may be a source of alternative antioxidants that may be beneficial in slowing or preventing the progression of various oxidative stress\u2010related diseases.<\/jats:p>","DOI":"10.1002\/cbdv.202301652","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T10:19:44Z","timestamp":1705659584000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Investigation of Phytochemical, Antioxidant and Antidiabetic Potentials of <i>Scabiosa<\/i> L. (Caprifoliaceae) Species with Chemometric Methods"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0253-3746","authenticated-orcid":false,"given":"Sevil","family":"Albayrak","sequence":"first","affiliation":[{"name":"Department of Biology Science Faculty Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9696-7122","authenticated-orcid":false,"given":"Ahmet","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Biology Science Faculty Akdeniz University  Antalya T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Abdullah","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Pharmacy Dicle University  Diyarbakir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0248-4227","authenticated-orcid":false,"given":"Erman","family":"Beyzi","sequence":"additional","affiliation":[{"name":"Department of Field Crops Faculty of Agriculture Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7616791"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02689-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.14235\/bas.galenos.2018.2486"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-009-9043-x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.24925\/turjaf.v4i12.1134-1138.1069"},{"key":"e_1_2_9_6_1","first-page":"225","volume":"3","author":"Anbudhasan P.","year":"2014","journal-title":"Int. J. Food Nutr. Sci."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2018.00001"},{"key":"e_1_2_9_8_1","first-page":"232","volume-title":"Environ. Sci. Eng. Toxicol.","author":"Abdel-Shafy H.","year":"2017"},{"key":"e_1_2_9_9_1","first-page":"42","volume-title":"Flora U.\u2005S.\u2005S.\u2005R. Vol. 24","author":"Bobrov E. G.","year":"1957"},{"key":"e_1_2_9_10_1","unstructured":"H. Deyuan M. Liming F.\u2005R. Barrie Flora China. Vol. 19 (Eds: Z.\u2005Y. Wu P.\u2005H. Raven D.\u2005Y. Hong) Science Press Beijing And Missouri Botanical Garden Press St. Louis. 2011 pp. 656\u2013659."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2699.2011.02669.x"},{"key":"e_1_2_9_12_1","first-page":"49","volume":"7","author":"Aksoy A.","year":"2020","journal-title":"Ba\u011fbah\u00e7e Bilim Derg."},{"key":"e_1_2_9_13_1","unstructured":"T. Baytop.Dictionary of Turkish Plant NamesAtat\u00fcrk K\u00fclt\u00fcr Dil Ve Tarih Y\u00fcksek Kurumu Ankara: T\u00fcrk Dil Kurumu Yay\u0131nlar\u0131 T\u00fcrk Tarih Kurumu Bas\u0131mevi. 1994."},{"key":"e_1_2_9_14_1","first-page":"319","volume-title":"T\u00fcrkiye Plants List (Vascular Plants)","author":"G\u00f6kt\u00fcrk R. S.","year":"2012"},{"key":"e_1_2_9_15_1","first-page":"178","author":"Panay\u0131r T.","year":"1996","journal-title":"Xl th Symp. Plant Orig. Crude Drugs"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201100191"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1305377"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(97)00982-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-008-9108-x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-1978(02)00070-4"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2010.01.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0304722"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2015.1027701"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.01.009"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-017-2666-9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12561"},{"key":"e_1_2_9_27_1","first-page":"398","volume":"4","author":"Ji M.","year":"2014","journal-title":"J. Inn. Mong. Univ. (Natural Sci. Ed.)"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)00460-X"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201600028"},{"key":"e_1_2_9_30_1","first-page":"1749","volume":"9","author":"Alipoor Birgani A.","year":"2019","journal-title":"J. Fasa Univ. Med. Sci."},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2015.03.035"},{"key":"e_1_2_9_32_1","unstructured":"K. \u00d6\u011f\u00fct Investigation of Phytochemicals and Biological Activities of Scabiosa pseudograminifoliaHUB.-MOR. Growing in Two Different Geographies Anadolu University Health Sciences Institute Master Thesis 2022 p. 96."},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23061285"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2021.12.004"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2020.112350"},{"key":"e_1_2_9_36_1","first-page":"934","volume":"11","author":"K\u0131l\u0131n\u00e7 H.","year":"2021","journal-title":"G\u00fcm\u00fc\u015fhane University Journal of Science and Technology"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.07.039"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf020342j"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifset.2009.05.009"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2012.746713"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13596-018-0320-3"},{"key":"e_1_2_9_42_1","unstructured":"M. T\u00fcrkaslan\u2005\u00c7o\u015fgun Investigation of Antioxidant Properties of Ethyl Acetate Extract from Scabiosa argentea Sel\u00e7uk University Graduate School of Natural and Applied Science Biology Department MS Thesis 2016 p. 26."},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637480600798132"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2011.02213.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(96)00151-1"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2017.12.018"},{"key":"e_1_2_9_47_1","first-page":"59","volume":"1","author":"Ben Hafsa M.","year":"2020","journal-title":"Tunis. J. Med. Plants Nat. Prod."},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr8020236"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2010.01.093"},{"key":"e_1_2_9_50_1","first-page":"001","volume":"7","author":"Benli M.","year":"2008","journal-title":"Afr. J. Biotechnol."},{"key":"e_1_2_9_51_1","first-page":"311","volume":"15","author":"Elhawary S. S.","year":"2011","journal-title":"World Appl. Sci. J."},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.12.033"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2010.05.031"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032719.2018.1528268"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637486.2019.1587742"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2020.112488"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2018.09.003"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocontrol.2011.02.010"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2020.112347"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.06.003"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.5530\/ijper.53.1.21"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2013.12.043"},{"key":"e_1_2_9_63_1","unstructured":"SPSS. IBM SPSS Statistics for Windows version XX (IBM Corp. Armonk N.Y. USA).2014."}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202301652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T23:27:17Z","timestamp":1741735637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202301652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,19]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/cbdv.202301652"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202301652","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,19]]},"assertion":[{"value":"2023-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202301652"}}