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Therefore, in this study, we successfully synthesized <jats:italic>Camellia sinensis<\/jats:italic> silver nanoparticles (CS\u2010AgNPs) biologically from methanolic leaf extract of <jats:italic>C. sinensis<\/jats:italic> and as confirmed by the visual appearance which exhibited strong absorption at 456\u2005nm in UV\u2010visible spectroscopy. The fourier transform infrared spectroscopy (FTIR) analysis revealed that phytochemicals of <jats:italic>C. sinensis<\/jats:italic> were coated with AgNPs. Scanning electron microscopy (SEM) analysis showed the spherical shape of CS\u2010AgNPs, with a size of 15.954\u2005nm, while X\u2010ray diffraction spectrometry (XRD) analysis detected a size of 20.32\u2005nm. Thermogravimetric analysis (TGA) indicated the thermal stability of CS\u2010AgNPs. The synthesized CS\u2010AgNPs significantly inhibited the ehrlich ascites carcinoma (EAC) cell growth with 53.42\u00b11.101\u2009%. The EAC cell line induced mice exhibited increased level of the serum aspartate aminotransferase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP), however this elevated serum parameter significantly reduced and controlled by the treatment with CS\u2010AgNPs. Moreover, in a streptozotocin\u2010induced diabetic mice model, CS\u2010AgNPs greatly reduced blood glucose, total cholesterol, triglyceride, low\u2010density lipoprotein (LDL) and creatinine levels. These findings highlight that the synthesized CS\u2010AgNPs have significant anticancer and antidiabetic activities that could be used as promising particles for the treatment of these major diseases. However, pre\u2010clinical and clinical trial should be addressed before use this particles as therapeutics agents.<\/jats:p>","DOI":"10.1002\/cbdv.202301661","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T18:34:05Z","timestamp":1708022045000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis of Silver Nanoparticles Using <i>Camellia sinensis<\/i> Leaf Extract: Promising Particles for the Treatment of Cancer and Diabetes"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-9717","authenticated-orcid":false,"given":"Md. Eram","family":"Hosen","sequence":"first","affiliation":[{"name":"Professor Joarder DNA and Chromosome Research Laboratory Department of Genetic Engineering and Biotechnology University of Rajshahi  Rajshahi 6205 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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Sojiur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Professor Joarder DNA and Chromosome Research Laboratory Department of Genetic Engineering and Biotechnology University of Rajshahi  Rajshahi 6205 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1751-705X","authenticated-orcid":false,"given":"Shopnil","family":"Akash","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Allied Health Sciences Daffodil International University  1216 Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Khalekuzzaman","sequence":"additional","affiliation":[{"name":"Professor Joarder DNA and Chromosome Research Laboratory Department of Genetic Engineering and Biotechnology University of Rajshahi  Rajshahi 6205 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz Abdullah","family":"Alsahli","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology College of Science King Saud University  Riyadh 11451 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3707-8461","authenticated-orcid":false,"given":"Mohammed","family":"Bourhia","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Natural Resources Valorization Faculty of Sciences Ibn Zohr University  Agadir 80060 Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba\u2010Allah","family":"Nafidi","sequence":"additional","affiliation":[{"name":"Department of Food Science Faculty of Agricultural and Food Sciences Laval University  2325 Quebec City QC G1V 0A6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3230-0118","authenticated-orcid":false,"given":"Md. 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