{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:06:54Z","timestamp":1753862814781,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012046","name":"Vietnam Academy of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>From the methanol extract of the <jats:italic>Cryptolepis buchananii<\/jats:italic> fruits, four undescribed pentacyclic triterpenene glycosides (<jats:bold>1<\/jats:bold>\u2013<jats:bold>4<\/jats:bold>) and five known pentacyclic triterpenenes (<jats:bold>5<\/jats:bold>\u2013<jats:bold>9<\/jats:bold>) were isolated. Their structures were determined to be uncargenin C 28\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010L\u2010rhamnopyranosyl\u2010(1\u21922)\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl ester (<jats:bold>1<\/jats:bold>), 3\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyluncargenin C 28\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010L\u2010rhamnopyranosyl\u2010(1\u21922)\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl ester (<jats:bold>2<\/jats:bold>), 3\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl\u2010(1\u21926)\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl\u20106<jats:italic>\u03b2<\/jats:italic>,23\u2010dihydroxyursolic acid 28\u2010O\u2010<jats:italic>\u03b1<\/jats:italic>\u2010L\u2010rhamnopyranosyl\u2010(1\u21922)\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl ester (<jats:bold>3<\/jats:bold>), 3\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl\u2010(1\u21922)\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosylasiatic acid 28\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010L\u2010rhamnopyranosyl\u2010(1\u21922)\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl ester (<jats:bold>4<\/jats:bold>), asiatic acid (<jats:bold>5<\/jats:bold>), 2<jats:italic>\u03b1<\/jats:italic>,3<jats:italic>\u03b2<\/jats:italic>,23\u2010trihydroxyoleana\u201011,13(18)\u2010dien\u201028\u2010oic acid (<jats:bold>6<\/jats:bold>), arjunolic acid (<jats:bold>7<\/jats:bold>), 6<jats:italic>\u03b2<\/jats:italic>\u2010hydroxyarjunolic acid (<jats:bold>8<\/jats:bold>), and actinidic acid (<jats:bold>9<\/jats:bold>) based on analyses of their HR\u2010ESI\u2010MS, 1D and 2D NMR spectra. All the isolates showed significantly NO production inhibition in LPS\u2010activated RAW264.7 cells with the IC<jats:sub>50<\/jats:sub> values ranging from 18.79 to 37.57\u2005\u03bcM, compared to that of the positive control compound, dexamethasone, which showed IC<jats:sub>50<\/jats:sub> value of 14.05\u2005\u03bcM.<\/jats:p>","DOI":"10.1002\/cbdv.202301683","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T03:34:41Z","timestamp":1701142481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Four New Pentacyclic Triterpene Glycosides Isolated from the Fruits of <i>Cryptolepis buchananii<\/i> R.Br. ex Roem. &amp; Schult and Their Inhibition of NO Production in LPS\u2010activated RAW264.7 Cells"],"prefix":"10.1002","volume":"20","author":[{"given":"Nguyen","family":"Duc Duy","sequence":"first","affiliation":[{"name":"Graduate University of Science and Technology VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"},{"name":"Center for High Technology Development VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngo","family":"Anh Bang","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pham","family":"Hai Yen","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do","family":"Thi Trang","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui","family":"Thi Nha Trang","sequence":"additional","affiliation":[{"name":"Hanoi University of Natural Resources and Environment  41\u2005A Phu Dien, North Tu Liem Hanoi 10000 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Thi Kim Thuy","sequence":"additional","affiliation":[{"name":"Center for High Technology Development VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Thi Cuc","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Xuan Nhiem","sequence":"additional","affiliation":[{"name":"Graduate University of Science and Technology VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"},{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan","family":"Van Kiem","sequence":"additional","affiliation":[{"name":"Graduate University of Science and Technology VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"},{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninh","family":"Khac Ban","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui","family":"Huu Tai","sequence":"additional","affiliation":[{"name":"Graduate University of Science and Technology VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"},{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,5]]},"reference":[{"key":"e_1_2_11_1_1","first-page":"337","volume":"1","author":"Bich D. 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