{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:23:27Z","timestamp":1789453407962,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current study aimed to evaluate the physicochemical properties of <jats:italic>Fernandoa adenophylla<\/jats:italic>. Powder studies were carried out to estimate the quantitative physicochemical characteristics of the crude drug, including moisture content, ash content, and extractive values. Using a Soxhlet apparatus and different analytical grade solvents, 3 sample extracts of a crude drug were made. To evaluate the potentially toxic nature, an acute oral toxicity study was performed as per OECD guideline no. 423. Sample extracts were tested and analyzed by ANOVA for pharmacological potential (analgesic, antipyretic, and antidiabetic) using Wister\u2010Albino rats. Where physicochemical analysis indicated purity, quality, and presence of organic\/inorganic materials in crude drug extracts, no sign of mortality was found up to 2000\u2005mg\/kg of body weight of <jats:italic>Fernandoa adenophyllas<\/jats:italic> extracts. Analgesic activity was observed in all sample extracts, whereas only chloroform and ethanolic extracts expressed antipyretic and antidiabetic potential. Ethanolic extract was found to be most potent in pharmacological potential as 200\u2005mg\/kg extract dose exhibited %age pain inhibition of 55.12\u2009% and reduced body temperature from 39.78\u00b10.03\u2009\u00b0C to 37.22\u00b10.02\u2009\u00b0C in hyperthermic rats. A decrease in blood glucose levels up to 57.88\u2009% was observed on the 21<jats:sup>st<\/jats:sup> day of the treatment with 500\u2005mg\/kg ethanolic extract.<\/jats:p>","DOI":"10.1002\/cbdv.202301724","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T15:54:34Z","timestamp":1712073274000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Physicochemical Evaluation and Pharmacological Screening of <i>Fernando Adenophylla Steenis<\/i> Fruits"],"prefix":"10.1002","volume":"21","author":[{"given":"Arham","family":"Hassan","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy The University of Lahore  Lahore 54000 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Asad","family":"Saeed","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of Central Punjab  Lahore 54782 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Zaman","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of Central Punjab  Lahore 54782 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazia","family":"Aslam","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy The University of Lahore  Lahore 54000 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahtab Ahmad","family":"Khan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of Central Punjab  Lahore 54782 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azmat Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Pharmaceutical Biotechnology Laboratory Department of Pharmaceutical Chemistry College of Pharmacy King Saud University  Riyadh 11451 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer M.","family":"Alanazi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Biotechnology Laboratory Department of Pharmaceutical Chemistry College of Pharmacy King Saud University  Riyadh 11451 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton Kumar","family":"Kundu","sequence":"additional","affiliation":[{"name":"Pharmacy discipline Khulna University Khulna  Gollamari Khulna 9208 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasi Rani","family":"Barai","sequence":"additional","affiliation":[{"name":"School of Mechanical and IT Engineering Yeungnam University  Gyeongsan 38541 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2206-7236","authenticated-orcid":false,"given":"Athanasios","family":"Alexiou","sequence":"additional","affiliation":[{"name":"University Centre for Research &amp; Development Chandigarh University  Chandigarh-Ludhiana Highway Mohali Punjab India"},{"name":"Department of Research &amp; Development  Funogen Athens 11741 Greece"},{"name":"Department of Research &amp; Development AFNP Med  Wien 1030 Austria"},{"name":"Department of Science and Engineering Novel Global Community Educational Foundation  Hebersham NSW-2770 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9020-874X","authenticated-orcid":false,"given":"Marios","family":"Papadakis","sequence":"additional","affiliation":[{"name":"Department of Surgery II University Hospital Witten-Herdecke  Heusnerstrasse 40 42283 Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2020.08.013"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1802343"},{"issue":"2","key":"e_1_2_11_3_1","first-page":"173","volume":"39","author":"Krishna G.","year":"2016","journal-title":"IJF"},{"issue":"3","key":"e_1_2_11_4_1","first-page":"236","volume":"4","author":"Rahmatullah M.","year":"2010","journal-title":"Adv. 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