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However, OCs differentiation and maturation is a complex regulatory process. In this study, we used a co\u2010culture system of RAW264.7 and MC3T3\u2010E1 cells under HG concentration to explore the effect of CYM on OCs in a HG environment. The effects of CYM on the formation and function of OCs were observed using TRAP\u2010positive cell counts and bone resorption pits. Then, mRNA and protein expression levels of OCs\u2010related genes were detected by real\u2010time qPCR and western blotting. The results showed that CYM had an inhibitory effect on OCs differentiation and bone resorption, reduced mRNAs expression of OCs\u2010associated genes, and downregulated RANKL\/RANK\/TRAF6 pathway that mediates OCs differentiation. CYM could be a promising natural compound against diabetic osteoporosis.<\/jats:p>","DOI":"10.1002\/cbdv.202301741","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:20:08Z","timestamp":1710343208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigating the Effects and Mechanisms of Cyclomorusin on Osteoclasts in a High Glucose Environment"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1140-1802","authenticated-orcid":false,"given":"Dong\u2010Gui","family":"Guo","sequence":"first","affiliation":[{"name":"College of Food and Pharmaceutical Engineering Guizhou Institute of Technology  Guiyang 550025 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"National &amp; Local Joint Engineering Research Center for the Exploition of Homology Resources of Southwest Medicine and Food Guizhou University  Guiyang 550025 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"National &amp; Local Joint Engineering Research Center for the Exploition of Homology Resources of Southwest Medicine and Food Guizhou University  Guiyang 550025 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u2010Wen","family":"Pan","sequence":"additional","affiliation":[{"name":"College of pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang 550025 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"e_1_2_11_1_1","first-page":"824","volume":"44","author":"Zhang L. 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