{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T10:39:36Z","timestamp":1783161576269,"version":"3.54.6"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In current study antioxidant, antidiabetic, antimicrobial, anticholinesterase, and human carbonic anhydrase I, and II (hCA I and II) isoenzymes inhibition activities of <jats:italic>Astrodaucus orientalis<\/jats:italic> different parts were investigated. Achetylcholinesterse (AChE) and butyrylcholinesterse (BChE) inhibitory activities of octyl acetate were determined via molecular docking. Quantitative assessment of specific secondary metabolites was conducted using LC\u2010MS\/MS. An examination of chemical composition of essential oils was carried out by GC\u2010MS\/MS. A thorough exploration of plant\u2018s anatomical characteristics was undertaken. The highest phenolics level and DPPH antioxidant capacity were seen in root and fruit. Fruit essential oil demonstrated the highest AChE inhibition (44.13\u00b13.61\u2009%), while root dichloromethane sub\u2010extract had the best inhibition towards BChE (86.13\u00b12.58\u2009%). Cytosolic hCA I, and II isoenzymes were influentially inhibited by root oil with 1.974 and 2.207\u2005\u03bcM IC<jats:sub>50<\/jats:sub> values, respectively. The most effective extracts were found to be root all extract\/sub\u2010extracts (except water) against <jats:italic>C. tropicalis<\/jats:italic> and <jats:italic>C. krusei<\/jats:italic> strains with MIC value 160&gt;\u03bcg\/mL. Sabinene (29.4\u2009%), \u03b1\u2010pinene (20.2\u2009%); octyl acetate (54.3\u2009%); myrcene (28.0\u2009%); octyl octanoate (71.3\u2009%) were found principal components of aerial parts, roots, flowers, and fruits, respectively. Flower essential oil, fruit dicloromethane and ethyl acetate exhibited potent <jats:italic>\u03b1<\/jats:italic>\u2010glucosidase inhibitory activity with 900, 40, and 937\u2005\u03bcg\/mL IC<jats:sub>50<\/jats:sub> values, respectively.<\/jats:p>","DOI":"10.1002\/cbdv.202301753","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T09:31:46Z","timestamp":1703842306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring <i>Astrodaucus orientalis<\/i> (L.) Drude: Phytochemical Analysis and its Biological Potential Against Alzheimer's and Diabetes"],"prefix":"10.1002","volume":"21","author":[{"given":"Hafize","family":"Yuca","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Ataturk University, Faculty of Pharmacy  Erzurum 25240 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilge","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Erzincan Binali Y\u0131ld\u0131r\u0131m University, Faculty of Pharmacy  Erzincan 24002 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3268-721X","authenticated-orcid":false,"given":"Songul","family":"Karakaya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany Ataturk University, Faculty of Pharmacy  Erzurum 25240 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Goger","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Afyonkarahisar Health University, Faculty of Pharmacy  Afyonkarahisar 03030 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynebe","family":"Bing\u00f6l","sequence":"additional","affiliation":[{"name":"Department of Medical Services and Techniques Gaziosmanpasa University, Vocational School of Health Services  Tokat 60000 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Civas","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Services Igdir University  Igdir 76400 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Ataturk University, Faculty of Pharmacy  Erzurum 25240 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bet\u00fcl","family":"Demirci","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Anadolu University, Faculty of Pharmacy  Eskisehir 26470 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Sytar","sequence":"additional","affiliation":[{"name":"Department of Plant Physiology Slovak University of Agriculture  Nitra 94976 Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhami","family":"Gulcin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ataturk University, Faculty of Science  Erzurum 25240 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhal","family":"Guvenalp","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Ataturk University, Faculty of Pharmacy  Erzurum 25240 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i6.889"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms131012629"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-0976"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2017.08.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2017.11.079"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13149"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00989"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf030698a"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.09.032"},{"key":"e_1_2_9_12_1","volume":"3","author":"Nazemiyeh H.","year":"2009","journal-title":"Rec. 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