{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:43:24Z","timestamp":1787503404640,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Several edible plants contain flavonoids, including myricetin (Myr), which perform a wide range of biological activities. Myr has antitumor properties against various tumor cells. In this study Myr\u2010loaded PEGylated niosomes (Myr\u2010PN) were prepared and their anti\u2010cancer activities were evaluated in\u2005vitro. Myr\u2010PNs were prepared as a tool for drug delivery to the tumor site. Myr\u2010PN was characterized in terms of size, zeta potential, and functional groups using dynamic light scattering (DLS), Fourier\u2010transform infrared spectroscopy (FTIR), and field emission scanning electron microscopy (SEM). The Myr\u2010PN size was 241\u2005nm with a polydispersity index (PDI) of 0.20, and zeta potential \u221232.7\u00b16.6\u2005mV. Apoptotic properties of Myr\u2010PN against normal and cancer cell lines were determined by flow cytometry and real\u2010time quantitative PCR. Cancer cells showed higher cytotoxicity when treated with Myr\u2010PN compared with normal cells, indicating that the synthesized nanoparticles pose no adverse effects. Apoptosis was induced in cells treated with 250\u2005\u03bcg\/mL of Myr\u2010PN, in which 45.2\u2009% of cells were arrested in subG1, suggesting that Myr\u2010PN can induce apoptosis. In vitro, the synthesized Myr\u2010PN demonstrated potent anticancer properties. Furthermore, more research should be conducted in\u2005vitro and in\u2005vivo to study the more details of Myr\u2010PN anti\u2010cancer effects.<\/jats:p>","DOI":"10.1002\/cbdv.202301767","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T09:14:33Z","timestamp":1710234873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Preparation of the Myricetin\u2010Loaded PEGylated Niosomes and Evaluation of their\n                    <i>in\u2005vitro<\/i>\n                    Anti\u2010Cancer Potentials"],"prefix":"10.1002","volume":"21","author":[{"given":"Hanieh","family":"Riazi","sequence":"first","affiliation":[{"name":"Department of Chemistry Shahrood Branch Islamic Azad University  Shahrood Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5546-5812","authenticated-orcid":false,"given":"Mohammad Taghi","family":"Goodarzi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Shahrood Branch Islamic Azad University  Shahrood Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud Homayouni","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"Department of Biology Mashhad Branch Islamic Azad University  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Mozaffari","sequence":"additional","affiliation":[{"name":"Department of Chemistry Herbal Medicines Raw Materials Research Center Shahrood Branch Islamic Azad University  Shahrood Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Neamati","sequence":"additional","affiliation":[{"name":"Department of Biology Mashhad Branch Islamic Azad University  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S128921"},{"key":"e_1_2_9_2_1","unstructured":"\u00a0"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2020.1870230"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2022.105226"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202201072"},{"key":"e_1_2_9_6_1","unstructured":"\u00a0"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13254"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100426"},{"key":"e_1_2_9_9_1","unstructured":"\u00a0"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2014.950564"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2020.112790"},{"key":"e_1_2_9_12_1","unstructured":"\u00a0"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199856050-00001"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-26400-x"},{"key":"e_1_2_9_15_1","unstructured":"\u00a0"},{"key":"e_1_2_9_16_2","first-page":"81","volume":"31","author":"Malhotra M.","year":"1994","journal-title":"Indian Drugs Bombay"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apt.2021.10.019"},{"key":"e_1_2_9_18_1","unstructured":"\u00a0"},{"key":"e_1_2_9_19_2","unstructured":"Solid lipid nanoparticles. 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