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According to traditional Chinese medicines theory, processing with vinegar can effectively reduce its toxicity. However, the detoxification processing technology of Myrrh and the corresponding mechanism have been unclear. The objective of this study is to systematically analyze the variation in chemical composition of raw Myrrh and its processed products using UPLC\u2010Q\u2010TOF\u2010MS\/MS coupled with chemometrics. A total of 75 compounds including 56 sesquiterpenoids, 2 diterpenoids, 15 triterpenoids and 2 other types were identified. Raw Myrrh and its processed products were divided into two major groups, and 14 chemical markers were selected out by principal component analysis and partial least square discriminant analysis. Additionally, the exact content of 5 representative chemical markers was determined to be significantly reduced after vinegar\u2010processing by UPLC\u2010QQQ\u2010MS\/MS. Moreover, multivariate statistical analysis and the quantitative results comprehensively indicated that the optimized processing method was processing at a ratio of 200\u2009:\u20095 (Myrrh:vinegar). This research provides not only a reliable foundation for the study of Myrrh, but also a scientific reference for clinical use of this herb.<\/jats:p>","DOI":"10.1002\/cbdv.202301782","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T05:59:50Z","timestamp":1706075990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chemometrics\u2010based Chemical Analysis of Myrrh and Its Vinegar\u2010processed Products by UPLC\u2010MS\/MS"],"prefix":"10.1002","volume":"21","author":[{"given":"Yuan","family":"Wang","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin 301617 P.R. 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