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The present study aimed to determine the antidiabetic activity of <jats:italic>C. angustifolia<\/jats:italic> rhizome <jats:italic>in\u2005vitro<\/jats:italic> and <jats:italic>in silico<\/jats:italic>. The methanolic extract of <jats:italic>C. angustifolia<\/jats:italic> rhizome was analyzed by FTIR and GC\u2010MS to determine the phytochemicals present. The antidiabetic potential of the extract was evaluated by different assays <jats:italic>in\u2009vitro<\/jats:italic>. The extract inhibited both \u03b1\u2010amylase and \u03b1\u2010glucosidase enzymes and the glucose diffusion through the dialysis membrane in a concentration\u2010dependent manner with IC<jats:sub>50<\/jats:sub> values of 530.39\u00b10.09, 293.75\u00b10.11, and 551.74\u00b10.3\u2005\u03bcg\/ml respectively. The methanolic extract also improved yeast cell's ability to take up glucose across plasma membranes and the adsorption of glucose. The findings were supported by molecular docking studies. The results showed that the methanol extract of <jats:italic>C. angustifolia<\/jats:italic> rhizome has significant antidiabetic activity and thus can be also studied to isolate the potential compound with antidiabetic activities.<\/jats:p>","DOI":"10.1002\/cbdv.202301788","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T18:47:53Z","timestamp":1710442073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Phytochemical Profiling and Assessment of Antidiabetic Activity of <i>Curcuma Angustifolia<\/i> Rhizome Methanolic Extract: An <i>In Vitro<\/i> and <i>In Silico<\/i> Analysis"],"prefix":"10.1002","volume":"21","author":[{"given":"P.","family":"Kavya","sequence":"first","affiliation":[{"name":"Department of Bio Medical Sciences, School of Bio Sciences and Technology Vellore Institute of Technology  Vellore Tamil Nadu 632014 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1087-2748","authenticated-orcid":false,"given":"M.","family":"Gayathri","sequence":"additional","affiliation":[{"name":"Department of Bio Medical Sciences, School of Bio Sciences and Technology Vellore Institute of Technology  Vellore Tamil Nadu 632014 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113739"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113781"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6659415"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13568-021-01219-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6625009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods10020315"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1660978"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2140-x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0508495"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.09.030"},{"key":"e_1_2_10_11_1","first-page":"154","volume":"11","author":"Sharma A.","year":"2012","journal-title":"Indian J. 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