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Despite recent advancements in pain therapies, the demand for more effective and well\u2010tolerated analgesics and anti\u2010inflammatories, particularly for chronic pain, remains. This study assessed the effects of essential oils from <jats:italic>Piper caldense<\/jats:italic>, <jats:italic>Piper mosenii<\/jats:italic>, and <jats:italic>Piper mikanianum<\/jats:italic> on nociceptive behavior induced by formalin and capsaicin, as well as their anti\u2010inflammatory impact induced by carrageenan, using adult zebrafish models. Results indicated non\u2010toxic essential oils with antinociceptive properties in both neurogenic and inflammatory phases of formalin\u2010induced nociception through interaction with the TRPA1 receptor. Additionally, <jats:italic>P. mosenii<\/jats:italic> essential oil also blocked the nociceptive effect of capsaicin, a TRPV1 receptor agonist. Furthermore, essential oils from <jats:italic>P. caldense<\/jats:italic> and <jats:italic>P. mikanianum<\/jats:italic> exhibited significant anti\u2010inflammatory effects by reducing carrageenan\u2010induced abdominal edema. These findings highlight the pharmacological potential of Piper's essential oils as antinociceptive and anti\u2010inflammatory agents.<\/jats:p>","DOI":"10.1002\/cbdv.202301807","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T12:39:09Z","timestamp":1706531949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Essential Oils from the Genus <i>Piper<\/i> Promote Antinociception by Modulating TRP Channels and Anti\u2010Inflammatory Effects in Adult Zebrafish"],"prefix":"10.1002","volume":"21","author":[{"given":"Wandresa Francelino","family":"Pereira","sequence":"first","affiliation":[{"name":"Postgraduate Program in Biotechnology \u2013 RENORBIO State University of Cear\u00e1  Fortaleza CE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz","family":"Everson da Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Sustainable 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