{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:06:49Z","timestamp":1753862809347,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Phytochemical investigation of the methanol extract from the fruits of <jats:italic>Macaranga monandra<\/jats:italic> <jats:bold>(Euphorbiaceae Muell. et Arg.)<\/jats:bold> afforded one new geranylated 1\u2019,2\u2019\u2010dihydrophenanthrene and two new flavonoid derivatives, named macamondrin (<jats:bold>1<\/jats:bold>), macamondrione A (<jats:bold>2<\/jats:bold>) and B (<jats:bold>3<\/jats:bold>) respectively. The structures of these compounds were elucidated mainly by NMR, mass spectral data and in comparison with data from the literature. Along with compounds <jats:bold>1<\/jats:bold>\u2013<jats:bold>3<\/jats:bold>, nine known compounds among which oleanolic acid (<jats:bold>4<\/jats:bold>); daucosterol (<jats:bold>5<\/jats:bold>); 3<jats:italic>\u03b2<\/jats:italic>\u2010acetoxy\u201011\u03b1,12<jats:italic>\u03b1<\/jats:italic>\u2010epoxytaraxerol (<jats:bold>6<\/jats:bold>); 3,3\u2019,4\u2010tri\u2010<jats:italic>O<\/jats:italic>\u2010methylellagic acid (<jats:bold>7<\/jats:bold>); 3,3\u2019,4,4\u2019\u2010tetra\u2010<jats:italic>O<\/jats:italic>\u2010methylellagic acid (<jats:bold>8<\/jats:bold>); 4\u2019\u2010<jats:italic>O<\/jats:italic>\u2010methyl\u20106\u2010isoprenylapigenin (<jats:bold>9<\/jats:bold>); 4\u2019\u2010<jats:italic>O<\/jats:italic>\u2010methyl\u20108 isoprenylkaempf\u00e9rol (<jats:bold>10<\/jats:bold>); 4\u2019\u2010<jats:italic>O<\/jats:italic>\u2010methyl\u20106\u2010isopr\u00e9nylkaempf\u00e9rol (<jats:bold>11<\/jats:bold>); 6\u2010isopr\u00e9nylkaempf\u00e9rol (<jats:bold>12<\/jats:bold>), were also isolated. Crude extracts as well as isolated compounds were evaluated for their antioxidant activity using the ABTS, DPPH and FRAP methods. It appears that the 50\u2009% radical scavenging concentrations ranging from 6.26 to 11.7\u2005\u03bcg\/ml on the ABTS radical, from 1.77 to 48.22\u2005\u03bcg\/ml on the DPPH radical, and from 1.54 to 67.97\u2005\u03bcg\/ml with the FRAP method. For the compounds tested, very good antioxidant activities were observed, which clearly shows that these molecules can have an anti oxidative stress potentiel.<\/jats:p>","DOI":"10.1002\/cbdv.202301816","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T19:14:33Z","timestamp":1718133273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Three New Polyphenol Derivatives from the Fruits of <i>Macaranga Monandra<\/i> and their Antioxidant Potential"],"prefix":"10.1002","volume":"21","author":[{"given":"Einstein","family":"Guizoko Toko","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry Faculty of Science University of Yaound\u00e9 I  P.O. Box\u2005812 Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlain","family":"Emar Djappa Tchapo","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Faculty of Science University of Yaound\u00e9 I  P.O. Box\u2005812 Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armelle","family":"Tontsa Tsamo","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Faculty of Science University of Yaound\u00e9 I  P.O. Box\u2005812 Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoul","family":"Kemzeu","sequence":"additional","affiliation":[{"name":"Antimicrobial and Biocontrol Agents Unit Laboratory for Phytobiochemistry and Medicinal Plants Studies Department of Biochemistry Faculty of Science University of Yaounde\u20051  P.O. Box\u2005812 Yaounde Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"H.E.J. Research Institute of Chemistry International Centre for Chemical and Biological Science (ICCBS) University of Karachi  75270 Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Boyom Fekam","sequence":"additional","affiliation":[{"name":"Antimicrobial and Biocontrol Agents Unit Laboratory for Phytobiochemistry and Medicinal Plants Studies Department of Biochemistry Faculty of Science University of Yaounde\u20051  P.O. Box\u2005812 Yaounde Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Tantoh Ndinteh","sequence":"additional","affiliation":[{"name":"Drug Discovery and Smart Molecules Research Laboratory Department of Chemical Sciences University of Johannesburg  Doornfontein, P.O. 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