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The bio\u2010activity of a new asperbutenolide A from marine fungus <jats:italic>Aspergillus terreus<\/jats:italic> was not well known. In the present study, the minimum inhibitory concentration (MIC) and RNA\u2010Sequencing were used to analyze the bio\u2010activity and sterilization mechanism of asperbutenolide A against clinical pathogenic microbes. The results showed that the MICs of asperbutenolide A against methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) were 4.0\u20138.0\u2005\u03bcg\/mL. The asperbutenolide A present poor bio\u2010activity against with <jats:italic>candida<\/jats:italic>. The sterilization mechanism of asperbutenolide A against MRSA showed that there were 1426 differentially\u2010expressed genes (DEGs) between the groups of MRSA treated with asperbutenolide A and negative control. Gene Ontology (GO) classification analysis indicated that the DEGs were mainly involved in cellular process, metabolic process, cellular anatomical entity, binding, catalytic activity, etc. Kyoto Encyclopedia of Genes and Genomes (KEGG) classification analysis showed that these DEGs were mainly enriched in amino acid metabolism, carbohydrate metabolism, membrane transport, etc. Moreover, qRT\u2010PCR showed similar trends in the expressions of <jats:italic>argF<\/jats:italic>, <jats:italic>ureA<\/jats:italic>, <jats:italic>glmS<\/jats:italic> and <jats:italic>opuCA<\/jats:italic> with the RNA\u2010Sequencing. These results indicated that asperbutenolide A was with ideal bio\u2010activity against with MRSA and could be as a new antibacterial agent.<\/jats:p>","DOI":"10.1002\/cbdv.202301826","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T07:05:46Z","timestamp":1703833546000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Biological Activity and Sterilization Mechanism of Marine Fungi\u2010derived Aromatic Butenolide Asperbutenolide A Against <i>Staphylococcus aureus<\/i>"],"prefix":"10.1002","volume":"21","author":[{"given":"Yufeng","family":"Jiang","sequence":"first","affiliation":[{"name":"Postdoctoral Mobile Station of Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"Medical Laboratory Jining No.1 People's Hospital  Jining Shandong China"},{"name":"Key Laboratory of Jining high-throughput gene sequencing Jining No.1 People's Hospital  Jining Shandong China"},{"name":"Key Laboratory of Jining Prenatal Monitoring and Genetic Disease Research Jining No.1 People's Hospital  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiule","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Laboratory Jining No.1 People's Hospital  Jining Shandong China"},{"name":"Jining Key Laboratory for the Intelligent Diagnosis of Emerging Infectious Diseases Jining No.1 People's Hospital  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology University of Jinan  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelu","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Laboratory Jining Dermatosis Prevention and Treatment Hospital  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Liang","sequence":"additional","affiliation":[{"name":"Medical Laboratory Jining No.1 People's Hospital  Jining Shandong China"},{"name":"Key Laboratory of Jining high-throughput gene sequencing Jining No.1 People's Hospital  Jining Shandong China"},{"name":"Key Laboratory of Jining Prenatal Monitoring and Genetic Disease Research Jining No.1 People's Hospital  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinli","family":"Xu","sequence":"additional","affiliation":[{"name":"Medical Laboratory Jining No.1 People's Hospital  Jining Shandong China"},{"name":"Key Laboratory of Jining high-throughput gene sequencing Jining No.1 People's Hospital  Jining Shandong China"},{"name":"Key Laboratory of Jining Prenatal Monitoring and Genetic Disease Research Jining No.1 People's Hospital  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Bao","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology University of Jinan  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0046-7260","authenticated-orcid":false,"given":"Biao","family":"Chen","sequence":"additional","affiliation":[{"name":"Central Laboratory Jining No.1 People's Hospital  Jining Shandong China"},{"name":"Jining Key Laboratory for the Intelligent Diagnosis of Emerging Infectious Diseases Jining No.1 People's Hospital  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c05750"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/md20090544"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2022.105377"},{"key":"e_1_2_11_4_1","volume":"19","author":"Mayer A. 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