{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:06:50Z","timestamp":1753862810849,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We discovered a new tetronomycin analog, C\u201032\u2010OH tetronomycin (<jats:bold>2<\/jats:bold>) from the <jats:italic>Streptomyces<\/jats:italic> sp. K20\u20100247 strain, which produces tetronomycin (<jats:bold>1<\/jats:bold>). After NMR analysis of <jats:bold>2<\/jats:bold>, we determined the planar structure. Futhermore, the absolute stereochemistry of <jats:bold>2<\/jats:bold> was deduced based on the biosynthetic pathway of <jats:bold>1<\/jats:bold> in the K20\u20100247 strain and a comparison of experimental electronic circular dichroism (ECD) results of <jats:bold>1<\/jats:bold> with <jats:bold>2<\/jats:bold>. While <jats:bold>2<\/jats:bold> exihibits potent antibacterial activity aganist Gram\u2010positive baceria including vancomycin\u2010intermediate <jats:italic>Staphylococcus aureus<\/jats:italic> (VISA) strains and vancomycin\u2010resistant <jats:italic>Enterococci<\/jats:italic> (VRE), the antibacterial activity of <jats:bold>2<\/jats:bold> shows 16\u201332\u2010folds weaker than that of <jats:bold>1<\/jats:bold> suggesting that the C\u201034 methyl group in <jats:bold>1<\/jats:bold> is one of the very important functinal group. Moreover, we evaluated the ionophore activity of <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> and neither compound shows ionophore activity at reasonable concetrations. Our research suggests that <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> would have different target(s) from an ionophore mechanism in the antibacterial activity and tetronomycins are promising natural products for broad\u2010spectrum antibiotics.<\/jats:p>","DOI":"10.1002\/cbdv.202301834","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T10:10:47Z","timestamp":1704449447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A new tetronomycin analog, broad\u2010spectrum and potent antibiotic against drug\u2010resistant Gram\u2010positive bacteria"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2625-1356","authenticated-orcid":false,"given":"Aoi","family":"Kimishima","sequence":"first","affiliation":[{"name":"Graduate School of Infection Control Sciences Kitasato University  5-9-1 Shirokane Minato-ku 108-8641 Tokyo 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Sciences Kitasato University  5-9-1 Shirokane Minato-ku 108-8641 Tokyo Japan"},{"name":"\u014cmura Satoshi Memorial Institute Kitasato University  5-9-1 Shirokane Minato-ku 108-8641 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-0117","authenticated-orcid":false,"given":"Miho","family":"Sugamata","sequence":"additional","affiliation":[{"name":"Graduate School of Infection Control Sciences Kitasato University  5-9-1 Shirokane Minato-ku 108-8641 Tokyo Japan"},{"name":"\u014cmura Satoshi Memorial Institute Kitasato University  5-9-1 Shirokane Minato-ku 108-8641 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7555-453X","authenticated-orcid":false,"given":"Paul","family":"Wasuwanich","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine  Gainesville FL 32610 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