{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:46:47Z","timestamp":1789534007230,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Psoralea corylifolia<\/jats:italic>\n                    (syn.\n                    <jats:italic>Cullen corylifolium<\/jats:italic>\n                    ), commonly called bawachi, is a medicinal plant extensively used for skin conditions like leukoderma, vitiligo, and psoriasis. It is notably rich in valuable bioactive compounds, particularly coumarins and furanocoumarins. This study isolated fourteen coumarins from\n                    <jats:italic>P.\u2005corylifolia<\/jats:italic>\n                    which were tested for cytotoxicity using the MTT assay, with compound\n                    <jats:bold>10<\/jats:bold>\n                    showing good cytotoxicity against A549 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    0.9\u2005\u03bcM), while compound\n                    <jats:bold>1<\/jats:bold>\n                    , compound\n                    <jats:bold>2<\/jats:bold>\n                    , and compound\n                    <jats:bold>3<\/jats:bold>\n                    displaying potential cytotoxicity against MDA\u2010MB\u2010231 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    0.49\u2005\u03bcM, 0.56\u2005\u03bcM, and 0.84\u2005\u03bcM respectively). Additionally, the compounds\u2032 interaction with Epidermal Growth Factor Receptor (EGFR) protein, highly expressed in both cell lines, was investigated through molecular modeling studies, that aligned well with cytotoxicity results. The findings revealed the remarkable cytotoxic potential of four coumarins\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>3<\/jats:bold>\n                    , and\n                    <jats:bold>10<\/jats:bold>\n                    against A549 and MDA\u2010MB\u2010231\u2005cell lines.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202301841","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T07:08:19Z","timestamp":1705388899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Isolation, Cytotoxicity, and\n                    <i>In\u2010silico<\/i>\n                    Screening of Coumarins from\n                    <i>Psoralea corylifolia<\/i>\n                    Linn."],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4193-6748","authenticated-orcid":false,"given":"Nancy","family":"Tripathi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering &amp; Technology Indian Institute of Technology Banaras Hindu University)  Varanasi 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarati","family":"Parmar","sequence":"additional","affiliation":[{"name":"B.D. Patel Institute of Paramedical Sciences Charotar University of Science &amp; Technology  CHARUSAT Campus Changa 388421 Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh","family":"Pandey","sequence":"additional","affiliation":[{"name":"B.D. Patel Institute of Paramedical Sciences Charotar University of Science &amp; Technology  CHARUSAT Campus Changa 388421 Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7857-9441","authenticated-orcid":false,"given":"Nivedita","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering &amp; Technology Indian Institute of Technology Banaras Hindu University)  Varanasi 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanheeta","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering &amp; Technology Indian Institute of Technology Banaras Hindu University)  Varanasi 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruma","family":"Sarkar","sequence":"additional","affiliation":[{"name":"B.D. Patel Institute of Paramedical Sciences Charotar University of Science &amp; Technology  CHARUSAT Campus Changa 388421 Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Kumar","sequence":"additional","affiliation":[{"name":"B.D. Patel Institute of Paramedical Sciences Charotar University of Science &amp; Technology  CHARUSAT Campus Changa 388421 Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6160-8755","authenticated-orcid":false,"given":"Shreyans K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering &amp; Technology Indian Institute of Technology Banaras Hindu University)  Varanasi 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570163811209020083"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020250"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X16500038"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5138\/ijpm.2010.0975.0185.02016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.65331"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2013.06.016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e06656"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.09.037"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf101064v"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.2005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(96)00703-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1139\/v69-591"},{"key":"e_1_2_8_14_1","first-page":"722","volume":"20","author":"Shawl A. 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