{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T13:48:47Z","timestamp":1781358527822,"version":"3.54.1"},"reference-count":67,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The paper is focused on biological activity and theoretical study of the structure and properties of a new azo derivative of \u03b2\u2010diketones and its complexes with some metals. The aim of our work was to study the structure and properties of the newly synthesized compound as well as to theoretically determine the possibility of complex formation with the Cu(II) or Co(II) ions. A compound with the same substituents R\n                    <jats:sub>1<\/jats:sub>\n                    =R\n                    <jats:sub>2<\/jats:sub>\n                    =CH\n                    <jats:sub>3<\/jats:sub>\n                    was chosen for the study. A synthesized azo compound based on 4\u2010amino antipyrine and its complexes with Cu(II), Co(II) in solution and solid phase is reported. The structures of these compounds have been testified by X\u2010ray, IR and \u00a0NMR spectroscopy. The combined experimental and theoretical approach was used. To study the structure and properties of the synthesized compound, as well as its possible complex formation with the Cu(II), quantum\u2010chemical calculations were carried out the 6\u201031G basis set and the electron density functional theory (DFT) method. These 3\u2010(1\u2010phenyl\u20102,3\u2010dimethyl\u2010pyrazolone\u20105) azopentadione\u20102,4 (PDPA) with Cu(II) and Co(II) complexes had effective inhibition against butyrylcholinesterase and acetylcholinesterase. IC\n                    <jats:sub>50<\/jats:sub>\n                    values were found as 19.03, 3.64\u2005\u03bcM for AChE and 28.47, 8.01\u2005\u03bcM for BChE, respectively. Cholinesterase inhibitors work to slow down the acetylcholine\u2018s deterioration.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202301861","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T14:44:45Z","timestamp":1708181085000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["New Azo Derivative of \u03b2\u2010Diketones and Its Cu(II), Co(II) Complexes: Synthesis, Theoretical Study and Biological Activity"],"prefix":"10.1002","volume":"21","author":[{"given":"Shahla","family":"Tahirli","sequence":"first","affiliation":[{"name":"Baku State University  Z. Khalilov Str. 23 1148 Baku Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastaran","family":"Sadeghian","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Faculty of Science Bartin University  Bartin T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farqana","family":"Aliyeva","sequence":"additional","affiliation":[{"name":"Baku State University  Z. Khalilov Str. 23 1148 Baku Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsun","family":"Sujayev","sequence":"additional","affiliation":[{"name":"Institute of Chemistry of additives named after acad. A.M.Guliyev  1029 Baku Azerbaijan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevilay","family":"G\u00fcnay","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Faculty of Science Bartin University  Bartin T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz","family":"Erden","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Faculty of Science Bartin University  Bartin T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namig","family":"Shikhaliyev","sequence":"additional","affiliation":[{"name":"Baku State University  Z. 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