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Antituberculosis, anti\u2010methicillin\u2010resistant Staphylococcus aureus (anti\u2010MRSA), antifungal, and larvicidal activities of the crude extract, two fractions, and seven isolated compounds from <jats:italic>Aspergillus terreus<\/jats:italic> derived from <jats:italic>Morus alba<\/jats:italic> roots were explored. The isolated compounds (5 butyrolactones and 2 orsellinic acid derivatives) showed potent to moderate antitubercular activity with MIC values ranging from 1.95 to 62.5\u2005\u03bcg\/mL (compared to isoniazid, 0.24\u2005\u03bcg\/mL) and promising anti\u2010MRSA potential with inhibition zone diameters ranging from 8 to 25\u2005mm. Additionally, the <jats:italic>in silico<\/jats:italic> study proved that the isolated compounds bind to the two corresponding proteins\u2019 active sites with high to moderate \u2013(C\u2013Docker interaction energies) and stable interactions. The isolated compounds displayed antifungal activities against different fungal strains at diverse degrees of activity, among them compound (8\u201cS,9\u201d)\u2010dihydroxy\u2010dihydrobutyrolactone I eliciting the best antifungal activity. Meanwhile, all isolated compounds, fractions, and the crude extract demonstrated extremely selective potent to moderate activity against <jats:italic>Cryptococcus neoformans<\/jats:italic>. The isolated five butyrolactone derivatives could develop potential mosquito larvicidal agents as a result of promising docking outcomes in the larval enzyme carboxylesterase.<\/jats:p>","DOI":"10.1002\/cbdv.202301900","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T03:20:00Z","timestamp":1706498400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Unveiling the Antimicrobial and Larvicidal Potential of Butyrolactones and Orsellinic Acid Derivatives from the <i>Morus alba\u2010<\/i>derived Fungus <i>Aspergillus terreus<\/i> via Integrated <i>In vitro<\/i> and <i>In silico<\/i> Approaches"],"prefix":"10.1002","volume":"21","author":[{"given":"Khadiga","family":"Amr","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain-Shams University  Organization of African Unity Street 1 11566 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Elissawy","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain-Shams University  Organization of African Unity Street 1 11566 Cairo Egypt"},{"name":"Center of Drug Discovery Research and Development Ain-Shams University  Organization of African Unity Street 1 11566 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain-Shams University  Organization of African Unity Street 1 11566 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Elnaggar","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain-Shams University  Organization of African Unity Street 1 11566 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iten M.","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department Faculty of Pharmacy Future University in Egypt  Cairo 12311 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-963X","authenticated-orcid":false,"given":"Abdel Nasser B.","family":"Singab","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain-Shams University  Organization of African Unity Street 1 11566 Cairo Egypt"},{"name":"Center of Drug Discovery Research and Development Ain-Shams University  Organization of African Unity Street 1 11566 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"e_1_2_11_1_1","volume-title":"Global antimicrobial resistance and use surveillance system (GLASS) report.","author":"Organization W. 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