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As praziquantel is the only available drug to treat schistosomiasis, there is a critical need to identify new anthelmintic compounds, particularly from natural sources. To enhance the activity of different natural products, one potential avenue involves its combination with silver nanoparticles (AgNP). Based on this approach, a one\u2010step green method for the <jats:italic>in\u2005situ<\/jats:italic> preparation of dehydrodieugenol (DHDG) by oxidation coupling reaction using silver and natural eugenol is presented. AgNP formation was confirmed by UV\u2010Vis spectroscopy due to the appearance of the surface plasmon resonance (SPR) band at 430\u2005nm which is characteristic of silver nanoparticles. The nanoparticles were spherical with sizes in the range of 40 to 50\u2005nm. Bioassays demonstrated that the silver nanoparticles loaded with DHDG exhibited significant anthelmintic activity against <jats:italic>Schistosoma mansoni<\/jats:italic> adult worms without toxicity to mammalian cells and an <jats:italic>in\u2005vivo<\/jats:italic> animal model (<jats:italic>Caenorhabditis elegans<\/jats:italic>), contributing to the development of new prototypes based on natural products for the treatment of schistosomiasis.<\/jats:p>","DOI":"10.1002\/cbdv.202301929","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T03:10:10Z","timestamp":1706325010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["In Situ Preparation of Dehydrodieugenol\u2010Loaded Silver Nanoparticles and their Antischistosomal Activity"],"prefix":"10.1002","volume":"21","author":[{"given":"Larissa V. 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