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The chard (<jats:italic>Beta vulgaris<\/jats:italic> L. var. cicla) is a unique plant which has a blood sugar\u2010lowering effect and powerful antioxidant activity. The aim of the current study was to investigate the possible protective effects of chard on AMD\u2010induced liver injury. Male Sprague\u2010Dawley rats were divided into four groups. Control group, aqueous chard extract given group 500\u2005mg\/kg\/day for one week, AMD given group 100\u2005mg\/kg\/day for one week, AMD+Chard given group (at the same doses and times). They were sacrificed on the 8th day. The blood and liver samples were taken. The serum and liver biochemical parameters were found to be changed in AMD treated group. Chard administration reversed these parameters in serum and liver. In histological experiments, necrotic areas, mononuclear cell infiltration, the endothelial rupture in central vein, sinusoidal dilatation, hyperemia, dark eosinophilic cells and picnotic nucleus were observed in liver tissues of AMD treated group. Chard treatment reduced liver tissue damage. Considering results, we can suggest that chard prevented AMD induced liver injury biochemically and histologically.<\/jats:p>","DOI":"10.1002\/cbdv.202301944","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T15:18:30Z","timestamp":1717773510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Beta vulgaris<\/i> L. var cicla Decreases Liver Injury Induced by Antiarrhytmic Agent, Amiodarone"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2789-5943","authenticated-orcid":false,"given":"Ismet Burcu","family":"Turkyilmaz","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Engineering Istanbul University-Cerrahpa\u015fa  Avcilar Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serap","family":"Sancar","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science Istanbul University  Vezneciler Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehnaz","family":"Bolkent","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science Istanbul University  Vezneciler Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Refiye","family":"Yanardag","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Engineering Istanbul University-Cerrahpa\u015fa  Avcilar Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i13.1373"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.08.039"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12594"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfs289"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.02.038"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2013.04.016"},{"key":"e_1_2_9_7_1","first-page":"223","volume":"7","author":"Abdul-Hamid M.","year":"2018","journal-title":"BJBAS."},{"key":"e_1_2_9_8_1","first-page":"87","volume":"16","author":"El-Sayed A. 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