{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:22:34Z","timestamp":1767612154508,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In Turkish folk medicine, the roots of\n                    <jats:italic>Onosma armeniacum<\/jats:italic>\n                    Klokov are used to heal wounds, burns, hemorrhoids, hoarseness, dyspnea, stomach ulcers, and abdominal aches. The objective was to evaluate the plant\u2018s ethnopharmacological applications using\n                    <jats:italic>in\u2005vivo<\/jats:italic>\n                    pharmacological experimental models.\n                    <jats:italic>In vivo<\/jats:italic>\n                    linear incision and circular excision the wound models were used to assess the wound healing activity along with histopathological investigation. The active component(s) were isolated and identified after being exposed to several chromatographic separation procedures on the primary extract. The\n                    <jats:italic>n<\/jats:italic>\n                    \u2010hexane\u2010dichloromethane mixture extract was subjected to chromatographic separation after the wound\u2010healing activity was confirmed. Deoxyshikonin (\n                    <jats:bold>1<\/jats:bold>\n                    ),\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010dimethylacrylshikonin (\n                    <jats:bold>2<\/jats:bold>\n                    ),\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010methyl\u2010\n                    <jats:italic>n<\/jats:italic>\n                    \u2010butylshikonin (\n                    <jats:bold>3<\/jats:bold>\n                    ), isovalerylshikonin (\n                    <jats:bold>4<\/jats:bold>\n                    ), acetylshikonin (\n                    <jats:bold>5<\/jats:bold>\n                    ),\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010hydroxyisovalerylshikonin (\n                    <jats:bold>6<\/jats:bold>\n                    ), and 5,8\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010dimethylacetylshikonin (\n                    <jats:bold>7<\/jats:bold>\n                    ) were identified as the structures of the isolated compounds. The efficacy of\n                    <jats:italic>O. armeniacum<\/jats:italic>\n                    to heal wounds was investigated in this study. Shikonin derivatives were identified as the primary active components of the roots by bioassay\u2010guided fractionation and isolation procedures.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202301946","type":"journal-article","created":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T22:05:04Z","timestamp":1709503504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Naphthoquinones from the Roots of\n                    <i>Onosma Armeniacum<\/i>\n                    Klokov on Wound Healing"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5829-7869","authenticated-orcid":false,"given":"Esra","family":"K\u00fcpeli Akkol","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Gazi University  Ankara 06330 T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu\u011fba","family":"Suba\u015f","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Karadeniz Technical University  61080 Trabzon T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ufuk","family":"\u00d6zgen","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Karadeniz Technical University  61080 Trabzon T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ipek","family":"S\u00fcntar","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Gazi University  Ankara 06330 T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mert","family":"Ilhan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy D\u00fczce University  D\u00fczce 81620 T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikmet","family":"Kele\u015f","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Medicine Afyon Kocatepe University  03200 Afyonkarahisar T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2016.08.013"},{"key":"e_1_2_8_2_1","first-page":"50","volume":"100","author":"Richardson M.","year":"2004","journal-title":"Nurs. 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