{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:50:42Z","timestamp":1773906642022,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2021243"],"award-info":[{"award-number":["A2021243"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A new alkaloids, aplysingoniopora A (\n                    <jats:bold>1<\/jats:bold>\n                    ), and new configuration pregnane type steroid compound, 9,17\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010pregn\u20101,4,20\u2010en\u20103\u2010one (\n                    <jats:bold>2<\/jats:bold>\n                    ), and two known pregnane type steroid compounds (\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>4<\/jats:bold>\n                    ) were isolated from hydranth of\n                    <jats:italic>Goniopora columna<\/jats:italic>\n                    corals. The compounds structures and absolute configurations were determined by extensive spectroscopic analysis, MS data, single\u2010crystal X\u2010ray diffraction analysis and quantum chemical calculation. The anticancer effect of the compounds were explored in human non\u2010small\u2010cell lung cancer (NSCLC) A549\u2005cell lines. As the results, the compound\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>4<\/jats:bold>\n                    induces toxicity and has proliferation inhibitory effects on A549 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    =58.99\u2005\n                    <jats:italic>\u03bc<\/jats:italic>\n                    M and 58.77\u2005\n                    <jats:italic>\u03bc<\/jats:italic>\n                    M, respectively) in\u2005vitro.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202301993","type":"journal-article","created":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T22:19:50Z","timestamp":1707689990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["New Alkaloids and Steroids from Hydranth of\n                    <i>Goniopora columna<\/i>\n                    Corals and Their Inhibiting Lung Cancer Cell Activities"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7055-4145","authenticated-orcid":false,"given":"Guangfu","family":"Feng","sequence":"first","affiliation":[{"name":"Institute of Marine Drugs Guangxi University of Chinese Medicine  Wuhe Road\u200513 530200 Nanning China"},{"name":"Guangxi Key Laboratory of Marine Drugs Guangxi University of Chinese Medicine  Wuhe Road\u200513 530200 Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieyi","family":"He","sequence":"additional","affiliation":[{"name":"The Marine Biomedical Research Institute Guangdong Medical University  Wenming East-Road\u20052 524023 Zhanjiang Guangdong China"},{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang  Wenming East-Road\u20052 524023 Zhanjiang Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiqi","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs Guangxi University of Chinese Medicine  Wuhe Road\u200513 530200 Nanning China"},{"name":"Guangxi Key Laboratory of Marine Drugs Guangxi University of Chinese Medicine  Wuhe Road\u200513 530200 Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Bai","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs Guangxi University of Chinese Medicine  Wuhe Road\u200513 530200 Nanning China"},{"name":"Guangxi Key Laboratory of Marine Drugs Guangxi University of Chinese Medicine  Wuhe Road\u200513 530200 Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs Guangxi University of Chinese Medicine  Wuhe Road\u200513 530200 Nanning China"},{"name":"Guangxi Key Laboratory of Marine Drugs Guangxi University of Chinese Medicine  Wuhe Road\u200513 530200 Nanning 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"346","volume-title":"Checklist of marine biota of china seas","author":"Liu R. 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