{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:53:01Z","timestamp":1787586781357,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to identify the phytochemical compounds of\n                    <jats:italic>Matricaria pubescens<\/jats:italic>\n                    by LC\u2013MS\/MS and evaluate the potential protective effect of its supplementation in\n                    <jats:bold>high<\/jats:bold>\n                    \u2010\n                    <jats:bold>fat diet<\/jats:bold>\n                    (HFD)\u2010induced non\u2010alcoholic fatty liver disease (NAFLD) in adult rats through modulation of oxidative stress and histopathological changes. Twenty\u2010four male rats were randomly divided into four groups. The first group served as control and received the standard diet. The second group (HFD) received a high\u2010fat diet only (30\u2009% of sheep fat). The third group\u2018s (control+MP) animals received a standard diet supplemented with 5\u2009%\n                    <jats:italic>M. pubescens<\/jats:italic>\n                    (\n                    <jats:italic>w\/w<\/jats:italic>\n                    ). The fourth group (HFD+MP) received a high\u2010fat diet supplemented with 5\u2009%\n                    <jats:italic>M. pubescens<\/jats:italic>\n                    for 16 weeks. LC\u2013MS\/MS analysis showed that\n                    <jats:italic>M. pubescens<\/jats:italic>\n                    contains many phytochemical compounds. It was observed that the ethanolic extract of\n                    <jats:italic>M. pubescens<\/jats:italic>\n                    has a higher phenolic content than the aqueous extract. The supplementation of\n                    <jats:italic>M. pubescens<\/jats:italic>\n                    (5\u2009%\n                    <jats:italic>w\/w<\/jats:italic>\n                    ) to HFD rats decreased significantly (p&lt;0.01) body weight, liver and epididymal adipose tissue relative weights, glycemia, triglycerides (TG), insulin resistance, liver markers, TNF\u2010\u03b1, malondialdehyde (MDA), protein carbonyl (PCO), advanced oxidation protein products (AOPP) level, and increased reduced glutathione (GSH) level, glutathione peroxidase (GPx), glutathione\u2010S\u2010transferase (GST), superoxide dismutase (SOD), and catalase activities as well as ameliorated histological alterations through the reduction hepatic lipid deposition and adipocytes hypertrophy compared to the HFD group. We conclude that\n                    <jats:italic>M. pubescens<\/jats:italic>\n                    powder may be effective for correcting hyperglycemia, hypertriglyceridemia, insulin resistance, and liver markers while decreasing inflammation and oxidative stress in the liver of high\u2010fat diet\u2010fed rats.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202302005","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T10:49:25Z","timestamp":1709808565000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Potential Hepatoprotective Effect of\n                    <i>Matricaria Pubescens<\/i>\n                    on High\u2010Fat Diet\u2010Induced Non\u2010Alcoholic Fatty Liver Disease in Rats"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0213-1517","authenticated-orcid":false,"given":"Houssem","family":"Chenna","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry and Environmental Toxicology Department of Biochemistry Faculty of Sciences University of Badji Mokhtar  BP 12 Sidi Amar Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9255-3854","authenticated-orcid":false,"given":"Yahia","family":"Khelef","sequence":"additional","affiliation":[{"name":"Laboratory of Biology Environment and Health Department of Cellular and Molecular Biology Faculty of Natural Science and Life El Oued University  El Oued Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0263-1909","authenticated-orcid":false,"given":"Imen","family":"Halimi","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and 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