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The preliminary antifungal assay suggested that the title derivatives showed moderate to good antifungal activity against six plant pathogens. Especially, compound <jats:bold>6\u2009e<\/jats:bold> presented excellent <jats:italic>in\u2005vitro<\/jats:italic> antifungal activity against <jats:italic>Sclerotinia sclerotiorum<\/jats:italic> (EC<jats:sub>50<\/jats:sub>=0.71\u2005mg\/L), which was substantially stronger than pydiflumetofen. <jats:italic>In vivo<\/jats:italic> antifungal assay indicated <jats:bold>6\u2009e<\/jats:bold> displayed prominent protective and curative effects on rape leaves infected by <jats:italic>S. sclerotiorum<\/jats:italic>. The preliminary mechanism research displayed that <jats:bold>6\u2009e<\/jats:bold> could damage the surface morpholog<jats:bold>y<\/jats:bold> and inhibit the sclerotia formation of <jats:italic>S. sclerotiorum<\/jats:italic>. In addition, the <jats:italic>in\u2005vitro<\/jats:italic> enzyme inhibition bioassay indicated that <jats:bold>6\u2009e<\/jats:bold> displayed pronounced laccase inhibition activity (IC<jats:sub>50<\/jats:sub>=0.63\u2005\u03bcM), much stronger than positive control cysteine. Molecular docking elucidated the binding modes between <jats:bold>6\u2009e<\/jats:bold> and laccase. The bioassay results and mechanism investigation demonstrated that this class of norbornene carboxamide\/sulfonamide derivatives could be promising laccase inhibitors for novel fungicide development.<\/jats:p>","DOI":"10.1002\/cbdv.202302033","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T02:14:31Z","timestamp":1713147271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis and Antifungal Activity of Norbornene Carboxamide\/sulfonamide Derivatives as Potential Fungicides Targeting Laccase"],"prefix":"10.1002","volume":"21","author":[{"given":"Zi\u2010Hui","family":"Yang","sequence":"first","affiliation":[{"name":"Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals College of Chemical Engineering Nanjing Forestry University  Nanjing 210037 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Gui","family":"Qiu","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals College of Chemical Engineering Nanjing Forestry University  Nanjing 210037 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dao\u2010Jun","family":"Jin","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals College of Chemical Engineering Nanjing Forestry University  Nanjing 210037 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals College of Chemical Engineering Nanjing Forestry University  Nanjing 210037 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"School of Foreign Languages Nanjing Xiaozhuang University  Nanjing 211171 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4499-4310","authenticated-orcid":false,"given":"Wen","family":"Gu","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals College of Chemical Engineering Nanjing Forestry University  Nanjing 210037 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c05475"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.114827"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2013.04.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5795"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.10.022"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c02056"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(02)00171-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/CT8834300472"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2006.04.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","unstructured":"M. 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