{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:08:00Z","timestamp":1790089680448,"version":"4.0.1"},"reference-count":86,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","award":["BUCM-2019-QNKXJC008"],"award-info":[{"award-number":["BUCM-2019-QNKXJC008"]}],"id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Tinospora sinensis<\/jats:italic> (<jats:italic>T. sinensis<\/jats:italic>), whose Tibetan name is \u201cLezhe\u201d, as a traditional medicine, is widely distributed in China, India and Sri Lanka. It is used for the treatment of rheumatic arthralgia, sciatica, lumbar muscle strain and bruises. Research over the previous decades indicated that <jats:italic>T. sinensis<\/jats:italic> mainly contains terpenes, lignans, alkaloids, phenol glycosides and other chemical components. A wide range of pharmacologic activities such as anti\u2010inflammatory, analgesic, immunosuppressive, anti\u2010aging, anti\u2010radiation, anti\u2010leishmania and liver protection have been reported. However, the scholar's research on the pharmacodynamic material basis of <jats:italic>T. sinensis<\/jats:italic> is relatively weak. Data regarding many aspects such as links between the traditional uses and bioactivities, pharmacokinetics, and quality control standard of active compositions is still limited and need more attention. This review reports a total of 241 compounds, the ethnopharmacology and clinical application of <jats:italic>T. sinensis<\/jats:italic>, covering the literature which were searched by multiple databases including Web of Science, PubMed, Google Scholar, Science Direct, CNKI and other literature sources from 1996 to date, with a view to provide a systematic and insightful reference and lays a foundation and inspiration for the application and further in\u2010depth research of <jats:italic>T. sinensis<\/jats:italic> resources.<\/jats:p>","DOI":"10.1002\/cbdv.202302037","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T15:49:19Z","timestamp":1711640959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Review on Traditional Uses, Phytochemistry, Pharmacology and Clinical Application of <i>Tinospora sinensis<\/i> (Lour.) Merr"],"prefix":"10.1002","volume":"21","author":[{"given":"Yan","family":"Liang","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing 102488 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010Bo","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing 102488 China"},{"name":"Beijing Youbo Pharmaceutical Co., Ltd.  Beijing 101300 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing 102488 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Ying","family":"Su","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing 102488 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Yuan","family":"Su","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing 102488 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-7794","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing 102488 China"},{"name":"The Key Research Laboratory of \u201cExploring Effective Substance in Classic and Famous Prescriptions of Traditional Chinese Medicine\u201d The State Administration of Traditional Chinese Medicine of the People's Republic of China  Beijing 102488 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing 102488 China"},{"name":"The Key Research Laboratory of \u201cExploring Effective Substance in Classic and Famous Prescriptions of Traditional Chinese Medicine\u201d The State Administration of Traditional Chinese Medicine of the People's Republic of China  Beijing 102488 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"e_1_2_15_1_1","unstructured":"Editorial Committee of Flora of China Flora of China Ke Xue Chu Ban She1996 30 pp. 20."},{"key":"e_1_2_15_2_1","unstructured":"Editorial Committee of Compilation of Chinas Medicinal Herb Compilation of China's Medicinal Herb People's Medical Publishing House (PMPH)1996 2 pp. 835."},{"key":"e_1_2_15_3_1","first-page":"2632","volume":"38","author":"Wu F. 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