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Medicinal plants such as <jats:italic>Lippia sidoides<\/jats:italic> and <jats:italic>Myracrodruon urundeuva<\/jats:italic> have shown interesting pharmacological activities, allied to this, the association of these medicinal plants and nanotechnology, could mean an advantage in relation to classical approach. This study investigated the effect of a nanogel loaded with <jats:italic>Lippia sidoides<\/jats:italic> essential oil and <jats:italic>Myracrodruon urundeuva<\/jats:italic> extract (NAA) in an excisional wound healing model in rats. Animals were anesthetized and skin wounds were made using a metal punch. The groups were treated with vehicle, NAA or collagenase gel, for 7, 14 or 21\u2005days and then sacrificed for tissue analysis. NAA did not show acute dermal irritation, further significantly reduced (p&lt;0.05) the final wound area, accelerated the wound contraction and organization of collagen in the group treated for 14\u2005days. The data presented here demonstrate the therapeutic potential for the use of nanotechnology associated with medicinal plants and provides evidence that corroborate with the use of <jats:italic>L.\u2005sidoides<\/jats:italic> and <jats:italic>M.\u2005urundeuva<\/jats:italic> as healing medicinal plants.<\/jats:p>","DOI":"10.1002\/cbdv.202302043","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T16:49:46Z","timestamp":1704732586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Wound Healing Effect of <i>Lippia sidoides<\/i> and <i>Myracrodruon urundeuva<\/i> Nanogel"],"prefix":"10.1002","volume":"21","author":[{"given":"Fernanda","family":"Pires Rodrigues de Almeida Ribeiro","sequence":"first","affiliation":[{"name":"Post-Graduation Program in Biotechnology State University of Feira de Santana (UEFS)  44036-900 Feira de Santana Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Fernandes Matos","sequence":"additional","affiliation":[{"name":"Center for Studies and Research of Medicinal Plants (NEPLAME) Federal University of Vale do S\u00e3o Francisco (UNIVASF)  56304-205 Petrolina Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinalva","family":"Brito Queiroz","sequence":"additional","affiliation":[{"name":"Biotechnology Postgraduate Program Potiguar University  59056-000 Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Ant\u00f4nio","family":"Botelho","sequence":"additional","affiliation":[{"name":"Biotechnology Postgraduate Program Potiguar University  59056-000 Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dra.Rosana","family":"de Souza Siqueira Barreto","sequence":"additional","affiliation":[{"name":"Federal University of Sergipe  49107-230 Aracaju Sergipe Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Santana de Lima","sequence":"additional","affiliation":[{"name":"Federal University of Vale do S\u00e3o Francisco (UNIVASF)  56304-205 Petrolina Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano Augusto","family":"de Ara\u00fajo Ribeiro","sequence":"additional","affiliation":[{"name":"Federal University of Vale do S\u00e3o Francisco (UNIVASF)  56304-205 Petrolina Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin","family":"Rose Alencar de Menezes","sequence":"additional","affiliation":[{"name":"Regional University of Cariri (URCA)  63105-000 Crato Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-4207","authenticated-orcid":false,"given":"Henrique Douglas","family":"Melo Coutinho","sequence":"additional","affiliation":[{"name":"Regional University of Cariri (URCA)  63105-000 Crato Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson Roberto","family":"Guedes da Silva Almeida","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Biotechnology State University of Feira de Santana (UEFS)  44036-900 Feira de Santana Bahia Brazil"},{"name":"Center for Studies and Research of Medicinal Plants (NEPLAME) Federal University of Vale do S\u00e3o Francisco (UNIVASF)  56304-205 Petrolina Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"e_1_2_12_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2011.06.009"},{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164741"},{"key":"e_1_2_12_3_1","first-page":"473","volume":"35","author":"Singh S.","year":"2017","journal-title":"Surgery."},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/190436"},{"key":"e_1_2_12_5_1","first-page":"2593","volume":"10","author":"Kalashnikova I.","year":"2015","journal-title":"Future Medicine"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.35086"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12132176"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101290"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(14)60104-8"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.02.030"},{"key":"e_1_2_12_11_1","first-page":"429","volume":"71","author":"Brito S. 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