{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:33:09Z","timestamp":1784032389749,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The antioxidant activity and the anti\u2010\u03b1\u2010amylase and anti\u2010acetylcholinesterase capacities of secondary metabolites from different organs (roots, stems, leaves and flowers) of Tunisian\n                    <jats:italic>Satureja barceloi<\/jats:italic>\n                    were determined. The variation in the distribution of phenolic metabolites among roots, stems, leaves and flowers extracts of\n                    <jats:italic>S.\u2005barceloi<\/jats:italic>\n                    with various solvent systems (methanol, ethyl acetate, hexane and distilled water) has not been characterized before. Significant variation of phenolic compounds was observed according to organs rather than to extracting solvents. The analyzed organs show a high level of phenolic compounds although the stems contains the highest total polyphenols (132.53\u00b10.48\u2005mg AGE\/g Ex), flavonoids (48.99\u00b10.65\u2005mg RE\/g Ex) and flavonols (34.93\u00b10.29\u2005mg QE\/g Ex) contents. The phenolic fraction was dominated by sagerinic acid, caffeic acid glucoside and epigallocatechin, detected using HPLC\u2010PDA\/ESI\u2010MS. The antioxidant activity of all extracts, evaluated by four\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    tests, was high and varied significantly according to the type of solvent used and the plant organ. The aqueous extracts of leaves exhibited the greatest inhibitory effect on alpha\u2010amylase while the methanolic extract of leaves and stems revealed the most important acetylcholinesterase inhibitory effect. Hence,\n                    <jats:italic>S.\u2005barceloi<\/jats:italic>\n                    extracts could be used as a source of various bioactive molecules in pharmaceutical industry.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202302109","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:35:23Z","timestamp":1708475723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Variation in Phenolic Content, Antioxidant Activity and Alpha\u2010amylase and Acetylcholinesterase Inhibitory Capacities of Different Extracts from Tunisian\n                    <i>Satureja barceloi<\/i>\n                    (Willk) L."],"prefix":"10.1002","volume":"21","author":[{"given":"Anhar","family":"Raadani","sequence":"first","affiliation":[{"name":"Laboratory of Nanobiotechnology and Valorisation of Medicinal Phytoresources National Institute of Applied Sciences and Technology. Department of Biology Carthage University B.P. 676  1080 Tunis Cedex Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdennacer","family":"Boulila","sequence":"additional","affiliation":[{"name":"Laboratoire des Substances Naturelles Institut National de Recherche et d'Analyse Physico-chimique Biotechnopole of Sidi Thabet  2020 Ariana Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islem","family":"Yangui","sequence":"additional","affiliation":[{"name":"Laboratory of Nanobiotechnology and Valorisation of Medicinal Phytoresources National Institute of Applied Sciences and Technology. Department of Biology Carthage University B.P. 676  1080 Tunis Cedex Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Boussaid","sequence":"additional","affiliation":[{"name":"Laboratory of Nanobiotechnology and Valorisation of Medicinal Phytoresources National Institute of Applied Sciences and Technology. Department of Biology Carthage University B.P. 676  1080 Tunis Cedex Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chokri","family":"Messaoud","sequence":"additional","affiliation":[{"name":"Laboratory of Nanobiotechnology and Valorisation of Medicinal Phytoresources National Institute of Applied Sciences and Technology. Department of Biology Carthage University B.P. 676  1080 Tunis Cedex Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Ben Elhadj Ali","sequence":"additional","affiliation":[{"name":"Laboratory of Nanobiotechnology and Valorisation of Medicinal Phytoresources National Institute of Applied Sciences and Technology. Department of Biology Carthage University B.P. 676  1080 Tunis Cedex Tunisia"},{"name":"Higher Institute of Biotechnology of Beja Jendouba University.  Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_12_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201600098"},{"key":"e_1_2_12_2_1","first-page":"1504","volume-title":"Techniques & documentations","author":"Bruneton J.","year":"2015"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2014.08.043"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.126930"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2019.10.002"},{"key":"e_1_2_12_6_1","first-page":"809","volume-title":"Flore de la Tunisie Angiospermes Dicotyl\u00e9dones Gamop\u00e9tales","author":"Pottier-Alapetite G.","year":"1981"},{"key":"e_1_2_12_7_1","volume-title":"Ecologie v\u00e9g\u00e9tale appliqu\u00e9e (I.\u2005O.\u2005R.)","author":"Nabli M. A.","year":"1995"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1678612"},{"key":"e_1_2_12_9_1","first-page":"70","volume":"20","author":"Brahmi F.","year":"2017","journal-title":"Int. J. Food Prop."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-018-9845-x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.12.028"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2014.08.021"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.07.069"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8070237"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2013.05.009"},{"key":"e_1_2_12_16_1","first-page":"575","volume":"66","author":"N'Guessan H. A.","year":"2011","journal-title":"Eur. J. Sci. Res."},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23061303"},{"key":"e_1_2_12_18_1","first-page":"14","volume":"9","author":"Bougandoura N.","year":"2013","journal-title":"Nat. Tech."},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16021454"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201400183"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2013.04.003"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.9734\/ARRB\/2018\/39217"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2012.02849.x"},{"key":"e_1_2_12_24_1","unstructured":"N. Benhammou Thesis. Universit\u00e9 Aboubakr Belka\u00efd-Tlemcen 2012. p 174."},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2012.12.028"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2006.10.003"},{"key":"e_1_2_12_27_1","first-page":"123","volume":"120","author":"Sekar V.","year":"2017","journal-title":"South Afr. J. Bot."},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.03.010"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm800115x"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.11.014"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.48048\/tis.2023.6202"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.02.054"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)99017-1"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.04.028"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.01.033"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO01930K"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-013-0991-1"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.08.049"},{"key":"e_1_2_12_39_1","unstructured":"SAS Incl Box 8000 Cary NC 27512\u20138000 Cary NC.1990."}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202302109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T09:17:27Z","timestamp":1762593447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202302109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/cbdv.202302109"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202302109","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,7]]},"assertion":[{"value":"2024-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202302109"}}