{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:19:59Z","timestamp":1791235199231,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012046","name":"Vietnam Academy of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three previously undescribed compounds named rauvolphyllas A\u2212C (<jats:bold>1\u20103<\/jats:bold>), along with thirteen known compounds, 18<jats:italic>\u03b2<\/jats:italic>\u2010hydroxy\u20103\u2010epi\u2010<jats:italic>\u03b1<\/jats:italic>\u2010yohimbine (<jats:bold>4<\/jats:bold>), yohimbine (<jats:bold>5<\/jats:bold>), <jats:italic>\u03b1<\/jats:italic>\u2010yohimbine (<jats:bold>6<\/jats:bold>), 17\u2010epi\u2010<jats:italic>\u03b1<\/jats:italic>\u2010yohimbine (<jats:bold>7<\/jats:bold>), (<jats:italic>E<\/jats:italic>)\u2010vallesiachotamine (<jats:bold>8<\/jats:bold>), (<jats:italic>Z<\/jats:italic>)\u2010vallesiachotamine (<jats:bold>9<\/jats:bold>), 16<jats:italic>S<\/jats:italic>\u2010<jats:italic>E<\/jats:italic>\u2010isositsirikine (<jats:bold>10<\/jats:bold>), N<jats:sub><jats:italic>b<\/jats:italic><\/jats:sub>\u2013methylisoajimaline (<jats:bold>11<\/jats:bold>), N<jats:sub><jats:italic>b<\/jats:italic><\/jats:sub>\u2013methylajimaline (<jats:bold>12<\/jats:bold>), ajimaline (<jats:bold>13<\/jats:bold>), (+)\u2010lyoniresinol 3\u03b1\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranoside (<jats:bold>14<\/jats:bold>), (+)\u2010isolarisiresinol 3\u03b1\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranoside (<jats:bold>15<\/jats:bold>), and (\u2212)\u2010lyoniresinol 3\u03b1\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranoside (<jats:bold>16<\/jats:bold>) were isolated from the aerial parts of <jats:italic>Rauvolfia tetraphylla<\/jats:italic> L. Their chemical structures were elucidated based on the extensive spectroscopic interpretation of HR\u2010ESI\u2010MS, 1D and 2D NMR spectra. The absolute configurations of <jats:bold>2<\/jats:bold> and <jats:bold>3<\/jats:bold> were determined by experimental ECD spectra. Compounds <jats:bold>5<\/jats:bold>, <jats:bold>6<\/jats:bold>, <jats:bold>7<\/jats:bold>, and <jats:bold>11<\/jats:bold>\u2013<jats:bold>13<\/jats:bold> exhibited nitric oxide production inhibition activity in LPS\u2010activated RAW 264.7 cells with the IC<jats:sub>50<\/jats:sub> values of 79.10, 44.34, 51.28, 33.54, 37.67, and 28.56\u2005\u03bcM, respectively, compared to that of the positive control, dexamethasone, which showed IC<jats:sub>50<\/jats:sub> value of 13.66\u2005\u03bcM. The other isolates were inactive with IC<jats:sub>50<\/jats:sub> values over 100\u2005\u03bcM.<\/jats:p>","DOI":"10.1002\/cbdv.202302123","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T03:55:17Z","timestamp":1705982117000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Alkaloids and Lignans from the Aerial Parts of <i>Rauvolfia tetraphylla<\/i> Inhibit NO Production in LPS\u2010activated RAW 264.7 Cells"],"prefix":"10.1002","volume":"21","author":[{"given":"Ninh Khac Thanh","family":"Tung","sequence":"first","affiliation":[{"name":"College of Pharmacy Chungnam National University  Daejeon 305-764 Korea"},{"name":"Center for High Technology Research and Development  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong Thi","family":"Dung","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan Van","family":"Kiem","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"},{"name":"Graduate University of Science and Technology, VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Thi Thuy","family":"Hang","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Xuan","family":"Nhiem","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"},{"name":"Graduate University of Science and Technology, VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Van","family":"The","sequence":"additional","affiliation":[{"name":"Traditional Medicine Hospital of Public Security Ministry of Vietnam  Hanoi 10000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Seo","sequence":"additional","affiliation":[{"name":"New Drug Development Center  Daegu-Gyeongbuk Medical Innovation Foundation (KMEDIhub 88 Dongnae-ro, Dong-gu Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Seong","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chungnam National University  Daejeon 305-764 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2034-3786","authenticated-orcid":false,"given":"Bui Huu","family":"Tai","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"},{"name":"Graduate University of Science and Technology, VAST  18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_11_1_1","first-page":"62","volume-title":"The Dictionary of Vietnamese Medicinal Plants","author":"Chi V. V.","year":"2018"},{"key":"e_1_2_11_2_1","first-page":"664","volume":"9","author":"Prashith T. R.","year":"2019","journal-title":"Int. J. Pharm. Biol. Sci."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1139\/v93-276"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-012-0220-6"},{"key":"e_1_2_11_5_1","first-page":"114","volume":"8","author":"Jakaria M. D.","year":"2016","journal-title":"J. Chem. Pharm. Res."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115327"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00147a014"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/np058007n"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.42.1924"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.58.720"},{"key":"e_1_2_11_11_1","first-page":"3247","volume":"36","author":"Ban N. K.","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2013.03.001"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/np000425z"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010103"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3987\/REV-98-512"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)82050-5"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-961451"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(98)00256-8"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13659-012-0012-5"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2012.04.029"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaa069"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/md8030429"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300372"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300093"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202302123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T06:39:38Z","timestamp":1710571178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202302123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/cbdv.202302123"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202302123","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,6]]},"assertion":[{"value":"2023-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202302123"}}