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Consequently, we have designed and synthesized 32 new amide\/sulfonamide dendrobine derivatives and screened their anti\u2010inflammatory activities in\u2005vitro. Experiments showed that nitric oxide (NO) generation in lipopolysaccharide (LPS)\u2010induced RAW264.7 cells was strongly reduced by derivative <jats:bold>14<\/jats:bold>, with an IC<jats:sub>50<\/jats:sub> of 2.96\u2005\u03bcM. Western blot research revealed that <jats:bold>14<\/jats:bold> decreased the concentration\u2010dependent expression of cyclooxygenase\u20102 (COX\u20102) and inducible nitric oxide synthase (INOS). Molecular docking was used to predict the binding of the inflammation\u2010associated proteins COX\u20102 and INOS to compound <jats:bold>14<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/cbdv.202400030","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T13:08:31Z","timestamp":1711026511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Synthesis and in\u2005vitro Anti\u2010Inflammatory Activity of Novel Dendrobine Amide\/Sulfonamide Derivatives"],"prefix":"10.1002","volume":"21","author":[{"given":"Zi\u2010Wei","family":"Jiao","sequence":"first","affiliation":[{"name":"School of Pharmacy Zunyi Medical University  Zunyi 563000 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University  Guiyang 550014 PR China"},{"name":"Natural Products Research Center of Guizhou Province  Guiyang 550014 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Qin","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University  Guiyang 550014 PR China"},{"name":"Natural Products Research Center of Guizhou Province  Guiyang 550014 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010Tong","family":"Xie","sequence":"additional","affiliation":[{"name":"Natural Products Research Center of Guizhou Province  Guiyang 550014 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua\u2010Yong","family":"Lou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University  Guiyang 550014 PR China"},{"name":"Natural Products Research Center of Guizhou Province  Guiyang 550014 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Dong","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guizhou University  Guiyang 550025 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3401-3412","authenticated-orcid":false,"given":"Mao\u2010Sheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Zunyi Medical University  Zunyi 563000 PR China"},{"name":"State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University  Guiyang 550014 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.01.006"},{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","unstructured":"R.\u2005R. 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