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The encapsulated extract was characterized using different analytical techniques. Furthermore, the loading efficiency and release of the plant extract were examined. FT\u2010IR spectroscopy confirmed the formation of an expectational product. The TEM and SEM imaging showed a spherical morphology for the prepared encapsulated extract. The average size of poly\u2010methyl\u2010methacrylate nanoparticles containing <jats:italic>Ephedra<\/jats:italic> extract was found to be approximately 47\u2005nm. The extract loading efficiency and encapsulation efficiency test demonstrated a dose\u2010depending behavior on <jats:italic>E. intermedia<\/jats:italic> extract for both analyses, which is highly advantageous for traversing biological barriers. The release assay shows a controlled release for the extract at phosphate buffer solution (PBS). A 38\u2009% release was calculated after 36\u2005hours. The results obtained from the present study reveal that encapsulating the plant extract is a suitable alternative to control and increase their medicinal properties.<\/jats:p>","DOI":"10.1002\/cbdv.202400033","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T06:17:23Z","timestamp":1710569843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Ephedra intermedia<\/i> Schrenk &amp; C. A. 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