{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:06:35Z","timestamp":1753862795773,"version":"3.41.2"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many <jats:italic>Vicia<\/jats:italic> species (Fabaceae) were proven to possess bioactive compounds with potential health beneficial properties. The present study was designed to determine the phenolic constituents, antioxidant and enzyme inhibition activities of aerial parts and seed of <jats:italic>V.\u2005peregrina<\/jats:italic>. Hexane, ethyl acetate and methanol extracts were prepared by maceration and aqueous extract by infusion. The chemical compositions of the extracts were determined using HPLC\u2010MS\/MS technology. The antioxidant activities were examined using various assays including free radical scavenging (ABTS and DPPH), reducing ability (CUPRAC and FRAP), metal chelation, and phosphomolybdenum. The enzyme inhibitory effects were investigated against cholinesterase, tyrosinase, amylase and glucosidase. The highest total phenolics and flavonoids contents were recorded in the methanol extracts of the seed (45.42\u2005mg GAE\/g) and aerial parts (40.33\u2005mg RE\/g) respectively. The aerial parts were characterized by higher accumulation of chlorogenic acid (9893.86\u2005\u03bcg\u2009g<jats:sup>\u22121<\/jats:sup>), isoquercitrin (9400.33\u2005\u03bcg\u2009g<jats:sup>\u22121<\/jats:sup>), delphindin 3,5 diglucoside (9113.28\u2005\u03bcg\u2009g<jats:sup>\u22121<\/jats:sup>), hyperoside (6337.09\u2005\u03bcg\u2009g<jats:sup>\u22121<\/jats:sup>), rutin (3489.83\u2005\u03bcg\u2009g<jats:sup>\u22121<\/jats:sup>) and kaempferol\u20103\u2010glucoside (2872.84\u2005\u03bcg\u2009g<jats:sup>\u22121<\/jats:sup>). Generally, the methanol and aqueous extracts of the two studied parts exerted the best antioxidant activity with highest anti\u2010DPPH (61.99\u2005mg TE\/g), anti\u2010ABTS (101.80\u2005mg TE\/g) and Cu<jats:sup>++<\/jats:sup> (16169\u2005mg TE\/g) and Fe<jats:sup>+++<\/jats:sup> (172,36\u2005mg TE\/g) reducing capacity were recorded from the seed methanol extract. Methanol extract of the seed showed the best anti\u2010tyrosinase activity (75.86\u2005mg KAE\/g). These results indicated that <jats:italic>V. peregrina<\/jats:italic> is rich with bioactive phenolics suggesting their use in different health promoting applications.<\/jats:p>","DOI":"10.1002\/cbdv.202400040","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T12:58:03Z","timestamp":1706101083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["HPLC\u2010MS\/MS Profiles, Antioxidant, Neuroprotective, Antidiabetic and Skin Protective Effects of Different Extracts of <i>Vicia peregrina<\/i> L. Collected from the Eastern Region of Turkey"],"prefix":"10.1002","volume":"21","author":[{"given":"Sakina","family":"Yagi","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lorraine INRAE, LAE  F-54000 Nancy France"},{"name":"Department of Botany Faculty of Science University of Khartoum  Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musa Denizhan","family":"Ulusan","sequence":"additional","affiliation":[{"name":"Isparta University of Applied Sciences Faculty of Forestry  Forest Engineering Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouadio Ibrahime","family":"Sinan","sequence":"additional","affiliation":[{"name":"Department of Biology Science Faculty Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Caprioli","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  62032 Camerino MC Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Mustafa","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  62032 Camerino MC Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Angeloni","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  62032 Camerino MC Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihriban","family":"Ah\u0131skal\u0131","sequence":"additional","affiliation":[{"name":"Deparment of Biology Graduate School of Natural and Applied Sciences Bursa Uludag University  Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biology Science Faculty Selcuk University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00606-017-1444-5"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11070947"},{"volume-title":"\u2032Vicia\u2032","year":"2010","author":"Bryant J. 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