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Interestingly, <jats:italic>Moringa oleifera (M. oleifera)<\/jats:italic> fruit peel, previously discarded as waste, contains an abundance of essential biomolecules and high nutritional value. This study focuses on the eco\u2010friendly synthesis of silver nanoparticles infused with <jats:italic>M. oleifera<\/jats:italic> peel extract biomolecules and their impact on regulating proinflammatory cytokines, as well as their potential anticancer effects against Wistar rats. The freshly synthesized nanoformulation underwent comprehensive characterization, followed by antihepatic cancer evaluation using a diethyl nitrosamine\u2010induced model (at a dose of 200\u2005mg\u2009kg<jats:sup>\u22121<\/jats:sup> BW). The study demonstrates a significant reduction in proinflammatory cytokines such as tumor necrosis factor\u2010\u03b1, interleukin\u20106, interleukin\u20101\u03b2, and nuclear factor kappa beta (NF\u2010\u03baB). Furthermore, it confirms that the newly biosynthesized silver nanoparticles exhibit additional potential against hepatic cancer due to their capped biomolecules.<\/jats:p>","DOI":"10.1002\/cbdv.202400059","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T03:33:46Z","timestamp":1712547226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phyto\u2010Fabrication of <i>Moringa Oleifera<\/i> Peel\u2010Sourced Silver Nanoparticles: A Promising Approach for Combating Hepatic Cancer by Targeting Proinflammatory Cytokines and Mitigating Cytokine Storms"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1670-4830","authenticated-orcid":false,"given":"Shahnawaz","family":"Sameem","sequence":"first","affiliation":[{"name":"Bioorganic and Medicinal Chemistry Research Laboratory Department of Pharmaceutical Sciences Sam Higginbottom University of Agriculture, Technology and Sciences  Prayagraj 211007 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0918-6062","authenticated-orcid":false,"given":"Vivek","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Bioorganic and Medicinal Chemistry Research Laboratory Department of Pharmaceutical Sciences Sam Higginbottom University of Agriculture, Technology and Sciences  Prayagraj 211007 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Kumar","sequence":"additional","affiliation":[{"name":"Natural Product Drug Discovery Laboratory, Department of Pharmaceutical Sciences Sam Higginbottom University of Agriculture, Technology and Sciences  Prayagraj 211007 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish R.","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry School of Pharmacy GITAM (Deemed to be University)  Hyderabad Campus 502329 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6160-9755","authenticated-orcid":false,"given":"Prateek","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis Quality Assurance and Pharmaceutical Chemistry School of Pharmacy GITAM (Deemed to be University)  Hyderabad Campus 502329 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhupendra","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Pharmacy Graphic Era Hill University  Dehradun 248002 India"},{"name":"Department of Pharmacy S. 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