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This study sought to perform a chemical analysis and evaluate the antitussive, expectorant and antipyretic effects of the ethanolic extract of <jats:italic>M. charantia<\/jats:italic> leaves (EEMc) in rats and mice. The EEMc was subjected to chemical analysis by HPLC\u2010DAD, revealing the presence of the flavonoids astragalin and isoquercetin. Acute oral toxicity in mice did not result in deaths, although changes in liver weight and stool consistency were observed. EEMc demonstrated an antitussive effect at doses of 100 and 300\u2005mg\/kg in mice subjected to cough induction by citric acid nebulization. Furthermore, it showed expectorant activity at a dose of 300\u2005mg\/kg, assessed based on the elimination of the phenol red marker in bronchoalveolar lavage. In the evaluation of antipyretic activity in rats, fever induced by <jats:italic>Saccharomyces cerevisiae<\/jats:italic> was reduced at all doses tested during the first hour after treatment. This innovative study identified the presence of astragalin and isoquercetin in EEMc and indicated that the extract has antitussive, expectorant and antipyretic properties. Therefore, EEMc presents itself as a promising option in herbal medicine for the treatment of respiratory symptoms and fever.<\/jats:p>","DOI":"10.1002\/cbdv.202400072","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T12:38:55Z","timestamp":1716467935000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antitussive, Expectorant and Antipyretic Effect of the Ethanolic Extract of the Leaves of <i>Momordica charantia<\/i> L."],"prefix":"10.1002","volume":"21","author":[{"given":"Tiago","family":"Feitosa Ribeiro","sequence":"first","affiliation":[{"name":"Central for Analysis of Drugs Medicines and Food (CAFMA) Federal University of Vale do S\u00e3o Francisco  Pernambuco Brazil"},{"name":"Northeast Network of Biotechnology (RENORBIO) Federal Rural University of Pernambuco (UFRPE)  Recife Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nath\u00e1lia 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