{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:30:15Z","timestamp":1790771415676,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903697"],"award-info":[{"award-number":["81903697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objectives<\/jats:bold>\n                    : Dandelion has been shown to exert anti\u2010inflammatory and anti\u2010bacterial effects. Our study aimed to identify the effect and mechanism of dandelion flower extracts on\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    \u2010induced gastritis and screen for novel antimicrobial substances.\n                    <jats:bold>Methods<\/jats:bold>\n                    : Anti\n                    <jats:italic>\u2010H.\u2005pylori<\/jats:italic>\n                    activities of water extracts(WEDF) and ethanol extracts (EEDF) of dandelion flowers were performed with disk diffusion method assay, MIC, and MBC. The\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    \u2010induced model was constructed to examine the gastroprotective of EEDF using RUT, pathological analysis, and ELISA.\n                    <jats:bold>Results<\/jats:bold>\n                    : EEDF exhibited better anti\u2010\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    and urease inhibition activities than WEDF.\n                    <jats:italic>In vivo<\/jats:italic>\n                    studies, EEDF can reduce the adhesion of\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    to the gastric mucosa, alleviate gastric damage, and concurrently reduce the levels of TNF\u2010\u03b1 and IL\u20106 in gastric tissues. The six phenolic compounds showed urease inhibition effect (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 2.99\u00b10.15 to 66.08\u00b16.46\u2005mmol\/mL). Among them, chlorogenic acid, caffeic acid, and luteolin also had anti\u2010\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    activity (MIC: 64\u2013256\u2005\u03bcg\/mL).\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : EEDF exhibited anti\u2010\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    , gastroprotective and anti\u2010inflammatory effects. Chicoric acid and luteolin may be the main active compounds of dandelion flowers to exert anti\u2010\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    , and worthy of further investigation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202400140","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T10:54:25Z","timestamp":1712141665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Potentialities of Dandelion (\n                    <i>Taraxacum Mongolicum<\/i>\n                    Hand.\u2010Mazz.) Flower Extracts on Gastric Protection against\n                    <i>Helicobacter Pylori<\/i>\n                    and Characterization of its Bioactive Constituents"],"prefix":"10.1002","volume":"21","author":[{"given":"Huirong","family":"Dong","sequence":"first","affiliation":[{"name":"School of Pharmacy Binzhou Medical University  264003 Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasen","family":"Qiao","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine Binzhou Medical University  264003 Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyao","family":"Hou","sequence":"additional","affiliation":[{"name":"School of Pharmacy Binzhou Medical University  264003 Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoqi","family":"Ran","sequence":"additional","affiliation":[{"name":"Zhifu District Center for Disease Control and Prevention  264000 Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihao","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Life Science and Biological Pharmacy Shenyang Pharmaceutical University  110016 Shenyang Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benfan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Jinzhou Medical University  121017 Jinzhou Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology Binzhou Medical University  264003 Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Binzhou Medical University  264003 Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3865-3547","authenticated-orcid":false,"given":"Yanni","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy Binzhou Medical University  264003 Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00164-X"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326170"},{"issue":"18","key":"e_1_2_9_3_1","first-page":"1","volume":"249","author":"Tsukamoto T.","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-017-0167-z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0515-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.08.016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.202200026"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.05.012"},{"key":"e_1_2_9_9_1","first-page":"198","volume":"6","author":"Fatima T.","year":"2018","journal-title":"J. Med. Plants Res."},{"key":"e_1_2_9_10_1","first-page":"1","volume":"293","author":"Li Y. N.","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/2008-2231-20-72"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2021.09.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1250027"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2021.1977-1987"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.06.045"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.02.013"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2017.08.002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/26415275.2020.1796674"},{"key":"e_1_2_9_19_1","first-page":"1","volume":"249","author":"Lu Q.","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56847-4"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022524313355"},{"key":"e_1_2_9_22_1","first-page":"6337","volume":"12","author":"Lin Q.","year":"2015","journal-title":"Mol. Med."}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202400140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T12:41:21Z","timestamp":1718714481000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202400140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/cbdv.202400140"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202400140","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,30]]},"assertion":[{"value":"2024-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202400140"}}