{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:19:44Z","timestamp":1773674384340,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current study describes the efficacy of <jats:italic>B. acutangula<\/jats:italic> fruit extract in wound healing <jats:italic>via<\/jats:italic> incorporation within topical gels. <jats:italic>B. acutangula<\/jats:italic> fruit extract was produced by solvent extraction method. The bioactive extract was incorporated within Carbopol 940\u2010based topical gels, which were applied topically over the excision and incision wounds. The change in healing process was observed till 20\u2005days. The percentages of closure of excision wound area were 92.89\u2009% and 93.43\u2009%, when treated with topical herbal gels containing <jats:italic>B. acutangula<\/jats:italic> fruit extract of 5\u2009% and 10\u2009%, respectively. The tensile strengths of incision area in rats treated with topical herbal gels containing 5\u2009% and 10\u2009% methanol extract of <jats:italic>B. acutangula<\/jats:italic> fruits were found to be 25\u00b15.12\u2005g and 30\u00b14.10\u2005g, respectively. The wound healing activity of topical herbal gels containing <jats:italic>B. acutangula<\/jats:italic> fruit extract in rats was found to be significant when compared with that of the reference standard and untreated groups. In addition, <jats:italic>in silico<\/jats:italic> studies suggested about good skin permeability and binding to the proteins responsible for delaying wound healing. It can be concluded that this topical herbal gels containing <jats:italic>B. acutangula<\/jats:italic> fruit extract could be used clinically for the treatment of wounds.<\/jats:p>","DOI":"10.1002\/cbdv.202400147","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T17:09:53Z","timestamp":1714496993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Wound Healing Activity of Topical Herbal Gels Containing <i>Barringtonia acutangula<\/i> Fruit Extract: <i>In silico and In vivo<\/i> Studies"],"prefix":"10.1002","volume":"21","author":[{"given":"Kumari","family":"Priyanka","sequence":"first","affiliation":[{"name":"Department of Pharmacy Usha Martin University  Ranchi 835103 Jharkhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudra Narayan","family":"Sahoo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Siksha \u2018O' Anusandhan (Deemed to be University)  Bhubaneswar 751003 Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashirbad","family":"Nanda","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Life Sciences Centurion University of Technology and Management  Bhubaneswar 752050 Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish","family":"Kanhar","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Life Sciences Centurion University of Technology and Management  Bhubaneswar 752050 Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandan","family":"Das","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Siksha \u2018O' Anusandhan (Deemed to be University)  Bhubaneswar 751003 Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijit","family":"Sahu","sequence":"additional","affiliation":[{"name":"Center of Excellence, Natural Products &amp; Therapeutics Department of Biotechnology and Bioinformatics Sambalpur University, Jyoti Vihar  Burla 768019 Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep Kumar","family":"Naik","sequence":"additional","affiliation":[{"name":"Center of Excellence, Natural Products &amp; Therapeutics Department of Biotechnology and Bioinformatics Sambalpur University, Jyoti Vihar  Burla 768019 Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3704-4619","authenticated-orcid":false,"given":"Amit Kumar","family":"Nayak","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Siksha \u2018O' Anusandhan (Deemed to be University)  Bhubaneswar 751003 Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2021.0114"},{"key":"e_1_2_10_2_1","first-page":"358","volume-title":"Alginates in Drug Delivery","author":"Kurakula M."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164741"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/20417314231185848"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.104602.2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2019.09.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbs021"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13237-022-00405-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2012.656850"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(14)60020-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.06.066"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.JPBS_175_19"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.01.014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2017.6.149"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/abr.abr_99_17"},{"issue":"11","key":"e_1_2_10_18_1","first-page":"1973","volume":"4","author":"Kumar J. 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