{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T09:22:18Z","timestamp":1762593738238,"version":"build-2065373602"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Kariavattom Campus Postmenopausal osteoporosis (PMO) is an old age disorder associated with estrogen deficiency, which reduces bone mass and makes bones more prone to fracture. The present study was proposed to evaluate the\n                    <jats:italic>invivo<\/jats:italic>\n                    osteogenic efficiency of\n                    <jats:italic>Pterospermum rubiginosum<\/jats:italic>\n                    methanolic bark extract (PRME) in the PMO model. Molecular docking studies on transcription factor NFATC1 showed excellent interactions with phytochemical ligands with the lowest binding energies. Female Sprague Dawley (SD) rats (n=24) were divided into four groups, (n=6 each) sham control (Group I) and osteoporotic control (Group II) groups treated with saline, PRME (50\u2005mg\/kg\/day) and alendronate (10\u2005mg\/kg\/day) treated with Group III and Group IV (n=6) respectively. The serum tartrate\u2010resistant acid phosphatase 5b and cathepsin\u2010K also exhibited a significant rise after PRME treatment 12.33\u00b12.30\u2005mU\/ml and 427.68\u00b146.97\u2005pg\/ml, respectively. DEXA results exhibited a remarkable increase in total bone mineral content and density values in PRME\u2010treated animals (0.175\u00b10.002\u2005g\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) and (7.95\u00b10.23\u2005g) when compared to osteoporotic control (0.163\u00b10.004\u2005g\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) and (6.83\u00b10.34 g). Long\u2010term toxicity study revealed that PRME is non\u2010toxic, up to 100\u2005mg\/kg bodyweight for 6\u2005months. Our findings suggest PRME protects osteoporotic SD rats from PMO damage resulting from estrogen deficiency by regulating bone remodelling markers and upregulating BMD indices.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202400172","type":"journal-article","created":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T22:29:58Z","timestamp":1708295398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting the Role of PRME in Regulating Bone Remodelling During Postmenopausal Osteoporosis"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4008-4256","authenticated-orcid":false,"given":"Anish Rajamohanan","family":"Jalaja","sequence":"first","affiliation":[{"name":"Department of Biochemistry University of Kerala, Kariavattom Campus, Trivandrum  Thiruvananthapuram 695581 India Tel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aswathy","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Kerala, Kariavattom Campus, Trivandrum  Thiruvananthapuram 695581 India Tel."},{"name":"Kerala State Palmyrah Products Development and Workers' Welfare Corporation Limited  Trivandrum India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayalakshmi","family":"Bindumadhavan","sequence":"additional","affiliation":[{"name":"Department of Computational Biology and Bioinformatics University of Kerala  Trivandrum India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelakanta Pillai Padmakumari","family":"Soumya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Kerala, Kariavattom Campus, Trivandrum  Thiruvananthapuram 695581 India Tel."},{"name":"Kerala State Animal Husbandry Department, Mararikulam south, Alappuzha  Kerala India ."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0919-4748","authenticated-orcid":false,"given":"Arun A.","family":"Rauf","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Kerala, Kariavattom Campus, Trivandrum  Thiruvananthapuram 695581 India Tel."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.69"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108998"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001831"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S54623"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12616"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.6118\/jmm.20015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-020-00150-x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.22271\/plants.2021.v9.i5a.1332"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116262"},{"key":"e_1_2_10_10_1","first-page":"89","volume":"19","author":"Yousefzadeh N.","year":"2020","journal-title":"EXCLI J."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0225"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2016.1238451"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020217"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.648084"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2015.94"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-019-0111-3"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103538"},{"key":"e_1_2_10_18_1","first-page":"687","volume":"9","author":"Anish R. 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