{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T09:22:55Z","timestamp":1762593775944,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21837003"],"award-info":[{"award-number":["21837003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202305AH340005"],"award-info":[{"award-number":["202305AH340005"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Voltage\u2010gated calcium channels (VGCCs), particularly T\u2010type calcium channels (TTCCs), are crucial for various physiological processes and have been implicated in pain, epilepsy, and cancer. Despite the clinical trials of TTCC blockers like Z944 and MK8998, none are currently available on the market. This study investigates the efficacy of\n                    <jats:italic>Lycopodium<\/jats:italic>\n                    alkaloids, particularly as natural product\u2010based TTCC blockers. We synthesized eighteen derivatives from\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010obscurine, a lycodine\u2010type alkaloid, and identified five derivatives with significant Ca\n                    <jats:sub>v<\/jats:sub>\n                    3.1 blockade activity. The most potent derivative, compound\n                    <jats:bold>7<\/jats:bold>\n                    , exhibited an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 0.19\u00b10.03\u2005\u03bcM and was further analyzed through molecular docking, revealing key interactions with Ca\n                    <jats:sub>v<\/jats:sub>\n                    3.1. These findings provide a foundation for the structural optimization of Ca\n                    <jats:sub>v<\/jats:sub>\n                    3.1 calcium channel blockers and present compound\n                    <jats:bold>7<\/jats:bold>\n                    as a promising lead compound for drug development and a tool for chemical biology research.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202400182","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T01:30:46Z","timestamp":1707269446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Discovery of\n                    <i>\u03b1<\/i>\n                    \u2010Obscurine Derivatives as Novel Ca\n                    <sub>v<\/sub>\n                    3.1 Calcium Channel Blockers"],"prefix":"10.1002","volume":"21","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences  Kunming 650201 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Yan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences  Kunming 650201 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zai\u2010Feng","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences  Kunming 650201 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1249-2917","authenticated-orcid":false,"given":"Qin\u2010Shi","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences  Kunming 650201 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.230"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.09.062"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000469"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12205"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11020134"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.009654"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.01.623"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2289"},{"key":"e_1_2_10_9_1","unstructured":"\u00a0"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01236"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200106000-00002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b02293"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106493"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b02056"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/b409720n"},{"key":"e_1_2_10_16_1","unstructured":"\u00a0"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b02065"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106962"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1139\/v53-126"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja101893b"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c00457"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01256"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC09060A"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"}],"container-title":["Chemistry &amp; 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