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The paper is focused on synthesis and study of alkoxymethyl derivatives of diheterocycloalkanes (<jats:bold>M1<\/jats:bold>\u2013<jats:bold>M15<\/jats:bold>) and inhibition effect on carbonic anhydrase and acetylcholinesterase. The structures of compounds were confirmed by <jats:sup>1<\/jats:sup>H and <jats:sup>13<\/jats:sup>C NMR spectroscopy. Also, in this study alkoxymethyl derivatives of diheterocycloalkanes were assessed for their influence on various metabolic enzymes, including acetylcholinesterase (AChE) and human carbonic anhydrase isoenzymes (hCA\u2005I and hCA\u2005II). The results demonstrated that all these compounds exhibited potent inhibitory effects on all the target enzymes, surpassing the standard inhibitors, as evidenced by their IC<jats:sub>50<\/jats:sub> and K<jats:sub>i<\/jats:sub> values. The K<jats:sub>i<\/jats:sub> values for the compounds concerning AChE, hCA\u2005I, and hCA\u2005II enzymes were in the ranges of 1.02\u00b10.17\u20138.38\u00b11.02, 15.30\u00b13.15\u201358.14\u00b15.17 and 24.05\u00b13.70\u2013312.94\u00b127.24\u2005nM, respectively.<\/jats:p>","DOI":"10.1002\/cbdv.202400296","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T02:07:00Z","timestamp":1712282820000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis and Inhibitor Effect Novel Alkoxymethyl Derivatives of Dihetero Cycloalkanes on Carbonic Anhydrase and Acetylcholinesterase"],"prefix":"10.1002","volume":"21","author":[{"given":"Vagif","family":"Farzaliyev","sequence":"first","affiliation":[{"name":"Institute of Chemistry of Additives Ministry of Science and Education of the Republic of Azerbaijan  1029 Baku Azerbaijan"},{"name":"Baku State University  Z. 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