{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:03:08Z","timestamp":1774598588973,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012046","name":"Vietnam Academy of Science and Technology","doi-asserted-by":"publisher","award":["THTEXS.04\/22-24"],"award-info":[{"award-number":["THTEXS.04\/22-24"]}],"id":[{"id":"10.13039\/100012046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study isolated pure compounds from <jats:italic>Canna edulis<\/jats:italic> aerial parts and assessed their antiplatelet and anticoagulant potential. Structural elucidation resulted in the identification of two new compounds: caneduloside A (<jats:bold>1<\/jats:bold>) and caneduloside B (<jats:bold>2<\/jats:bold>), and eleven known compounds: 6\u2019\u2010acetyl\u20103,6,2\u2019\u2010tri\u2010p\u2010coumaroyl sucrose (<jats:bold>3<\/jats:bold>), 6\u2032\u2010acetyl\u20103,6,2\u2032\u2010triferuloyl sucrose (<jats:bold>4<\/jats:bold>), tiliroside (<jats:bold>5<\/jats:bold>), afzelin (<jats:bold>6<\/jats:bold>), quercitrin (<jats:bold>7<\/jats:bold>), 2\u2010hydroxycinnamaldehyde (<jats:bold>8<\/jats:bold>), cinnamic acid (<jats:bold>9<\/jats:bold>), 3,4\u2010dimethoxycinnamic acid (<jats:bold>10<\/jats:bold>), dehydrovomifoliol (<jats:bold>11<\/jats:bold>), 4\u2010hydroxy\u20103,5\u2010dimethoxybenzaldehyde (<jats:bold>12<\/jats:bold>), and (S)\u2010(\u2212)\u2010rosmarinic acid (<jats:bold>13<\/jats:bold>). Compounds <jats:bold>3<\/jats:bold>, <jats:bold>4<\/jats:bold>, <jats:bold>6\u20139<\/jats:bold>, <jats:bold>13<\/jats:bold> were previously reported for antithrombotic properties. Hence, antithrombotic tests were conducted for <jats:bold>1<\/jats:bold>, <jats:bold>2<\/jats:bold>, <jats:bold>5<\/jats:bold>, <jats:bold>10\u201312<\/jats:bold>. All tested compounds demonstrated a dose\u2010dependent antiaggregatory effect, and <jats:bold>10<\/jats:bold> and <jats:bold>12<\/jats:bold> were the most potent for both ADP and collagen activators. Additionally, <jats:bold>10<\/jats:bold> and <jats:bold>12<\/jats:bold> showed anticoagulant effects, with prolonged prothrombin time and activated partial thromboplastin time. The new compound <jats:bold>1<\/jats:bold> displayed antiplatelet and anticoagulant activity, while <jats:bold>2<\/jats:bold> mildly inhibited platelet aggregation. <jats:italic>C. edulis<\/jats:italic> is a potential source for developing antithrombotic agents.<\/jats:p>","DOI":"10.1002\/cbdv.202400302","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T08:38:56Z","timestamp":1709887136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antiplatelet and Anticoagulant Effects of Two New Phenylpropanoid Sucrose Esters and Other Secondary Metabolites from the Aerial Part of <i>Canna edulis<\/i>"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5084-8347","authenticated-orcid":false,"given":"Thi Van Anh","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Life Sciences University of Science and Technology of Hanoi Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Minh Hang","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center of Drug Research and Development Institute of Marine Biochemistry Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Thoa","family":"Ha","sequence":"additional","affiliation":[{"name":"Center of Drug Research and Development Institute of Marine Biochemistry Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy Duong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Hanoi University of Pharmacy  13-15 Le Thanh Tong, Hoan Kiem Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duc Huy","family":"Bui","sequence":"additional","affiliation":[{"name":"Department of Life Sciences University of Science and Technology of Hanoi Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5619"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-017-1546-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113136"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5530\/ax.2012.2.5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.12928\/pharmaciana.v11i1.18063"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.11.100"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.07.153"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.10831"},{"key":"e_1_2_10_9_1","first-page":"385","volume":"28","author":"Nguyen T. V. A.","year":"2023","journal-title":"J. Med. Mater"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-019-02312-w"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/np010338m"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/np010222q"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2023.2297261"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711796391589"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0400104"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.20307\/nps.2017.23.2.139"},{"key":"e_1_2_10_17_1","first-page":"679","volume":"26","author":"Lee S. Y.","year":"2019","journal-title":"Int. Food Res. J."},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.10.028"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2004.08.011"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2010.529806"},{"key":"e_1_2_10_21_1","volume":"23","author":"Yuan Z.","year":"2018","journal-title":"Molecules"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/b916969e"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1139\/v97-612"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2875"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.131.1103"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880200903008641"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2009.1365"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c01176"},{"key":"e_1_2_10_29_1","first-page":"487","volume":"9","author":"Ngoc T. M.","year":"2014","journal-title":"Nat. Prod. Commun."},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711795471347"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2004.11.013"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.08.021"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23215"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2023.105872"},{"key":"e_1_2_10_35_1","first-page":"273","volume":"87","author":"Hitl M.","year":"2020","journal-title":"Planta Med."},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2012.596"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2014.271"},{"key":"e_1_2_10_38_1","first-page":"153","volume":"38","author":"Ghaly N.","year":"2010","journal-title":"Rev. Latinoam. Quim."},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c04320"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-15-5-214"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-199611000-00008"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/8782892"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40816-023-00359-2"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-66.10.1811"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2007.09.006"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959719"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.5567\/pharmacologia.2016.103.113"},{"key":"e_1_2_10_48_1","volume":"25","author":"Kim Y. J.","year":"2020","journal-title":"Molecules"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/np020058m"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23010072"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.58.1236"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2022.03.035"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43450-023-00472-w"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1683-5599"},{"key":"e_1_2_10_55_1","volume":"12","author":"Le H. L.","year":"2020","journal-title":"Pharmacog Res."},{"key":"e_1_2_10_56_1","first-page":"30","volume":"2","author":"Nguyen T. V. A.","year":"2018","journal-title":"Asian J. Pharm."}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202400302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T08:55:12Z","timestamp":1741769712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202400302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,27]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/cbdv.202400302"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202400302","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,27]]},"assertion":[{"value":"2024-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202400302"}}