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Diabetic rats were treated with Sidr honey daily for 4 consecutive weeks. The biochemical profile of blood samples was measured. Furthermore, the activity of antioxidant enzymes, nitric oxide (NO), and malonaldehyde (MDA) were examined in hepatic and pancreatic tissues. Moreover, the expression of Bax, Caspase\u20103, and Bcl2 proteins were measured. Results revealed that the capability of Sidr honey to decline the elevated blood glucose and fructosamine levels. Also, the honey decreased the levels of NO and MDA. Furthermore, it regulated the antioxidant enzymes activity. Moreover, it reduced the expression levels of Caspase\u20103 and Bax while increased the Bcl2 level. In conclusion, Sidr honey can regulate hyperglycemia, oxidative stress, apoptosis, and antioxidant enzymes in STZ\u2010induced diabetic rats.<\/jats:p>","DOI":"10.1002\/cbdv.202400351","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T12:28:40Z","timestamp":1715171320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Regulation of Oxidative Stress and Apoptosis in Streptozotocin\u2010Induced Diabetic Rats by Egyptian Sidr Honey"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8520-347X","authenticated-orcid":false,"given":"Bishoy","family":"El\u2010Aarag","sequence":"first","affiliation":[{"name":"Biochemistry Division, Chemistry Department, Faculty of Science Menoufia University  Shebin El-Koom 32512 Egypt"},{"name":"Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus  Irvine CA 92618 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar Bahgat","family":"Shehata","sequence":"additional","affiliation":[{"name":"Biochemistry Division, Chemistry Department, Faculty of Science Menoufia University  Shebin El-Koom 32512 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam M.","family":"El\u2010Garawani","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science Menoufia University  Shebin El-Koom 32512 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham R.","family":"El\u2010Seedi","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science Menoufia University  Shebin El-Koom 32512 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany Ebrahim","family":"Nofal","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science Menoufia University  Shebin El-Koom 32512 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119697473"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119697473.ch71"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsad070"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.2004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2022.03.015"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5570939"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/2251-6581-12-60"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0886-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112633"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26097"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24402"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-016-0303-y"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/829070"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530320666200729113954"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2023.102788"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-020-03536-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/15538362.2021.1995570"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1328"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aoas.2015.10.015"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/separations10070372"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2015.3.3"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2018.05.011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1320"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2020.101329"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2021.04.069"},{"key":"e_1_2_10_26_1","first-page":"45","volume":"11","author":"Oguntibeju O. 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