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The interaction of the diaqua complex with CT\u2010DNA and BSA was studied through various techniques, including UV\u2010vis spectroscopy, thermal denaturation, viscometry, gel electrophoresis, ethanol precipitation, and molecular docking studies. The results indicate that the complex exhibits a robust binding interaction with CT\u2010DNA, possibly via minor groove binding and (or) electrostatic interactions. Furthermore, the complex displays good binding affinity towards BSA, indicating its potential as a target for DNA and BSA in biological media. The invitro cytotoxicity assay reveals that this complex can be classified as a promising cell growth inhibitor against MCF\u20107, HT\u201029, and A549. Thus, this newly synthesized palladium (II) complex is a promising candidate for further exploration as a potential anticancer therapeutic.<\/jats:p>","DOI":"10.1002\/cbdv.202400415","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T02:35:11Z","timestamp":1721615711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis, Characterization, DNA Binding, Biological Significance, and Molecular Docking Approaches of a Palladium(II) Complex with Ciprofloxacin for More Efficient Therapy"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6464-4508","authenticated-orcid":false,"given":"Ramy G.","family":"Seddik","sequence":"first","affiliation":[{"name":"Biochemistry Division Chemistry Department Faculty of Science Cairo University  Giza Egypt"},{"name":"Faculty of Science Galala University  43511 Suze Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-0856","authenticated-orcid":false,"given":"Fatma B.","family":"Rashidi","sequence":"additional","affiliation":[{"name":"Biochemistry Division Chemistry Department Faculty of Science Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa S.","family":"Salah\u2010Eldin","sequence":"additional","affiliation":[{"name":"Biochemistry Division Chemistry Department Faculty of Science Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azza A.","family":"Shoukry","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry Division Chemistry Department Faculty of Science Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10953-014-0164-5"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2008.11.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202301170"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2014.900664"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2006.09.015"},{"key":"e_1_2_9_6_1","first-page":"1","volume":"18","author":"Elgedany H. 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