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This study aims to investigate the hepatoprotective effect of FA and its derivatives (methyl ferulic acid and <jats:italic>trans<\/jats:italic>\u2010ferulic acid) against oxidative stress and inflammation\u2010related hepatotoxicity due to toxicants based on the results of different non\u2010clinical and preclinical tests. For this, data was collected from different reliable electronic databases such as PubMed, Google Scholar, and ScienceDirect, etc. The results of this investigation demonstrated that FA and its derivatives have potent hepatoprotective effects against oxidative stress and inflammation\u2010related damage. The findings also revealed that these protective effects are due to the antioxidant and anti\u2010inflammatory effects of the chemical compound. FA and its analogues significantly inhibit free radical generation and hinder the effects of proinflammatory markers and inflammatory enzymes, resulting in diminished cytotoxic and apoptotic hepatocyte death. The compounds also prevent intracellular lipid accumulation and provide protective effects.<\/jats:p>","DOI":"10.1002\/cbdv.202400443","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T11:49:36Z","timestamp":1715946576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Therapeutic Promises of Ferulic Acid and its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-9720","authenticated-orcid":false,"given":"Md. 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