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In Greece, 54 <jats:italic>Stachys<\/jats:italic> taxa are found in parts of the mainland and\/or insular country. The present study focused on the phytochemical investigation of <jats:italic>Stachys iva<\/jats:italic> Griseb. and the <jats:italic>in\u2005vitro<\/jats:italic> anti\u2010inflammatory evaluation of the isolated compounds. In total, eighteen compounds were isolated and identified from the dichloromethane\u2010methanol extract, belonging to iridoids, flavonoids, phenylethanoid glycosides, and phenolic acids. An <jats:italic>in\u2005vitro<\/jats:italic> approach assessed the aryl hydrocarbon receptor (AhR) modulatory effects of these compounds, revealing an AhR agonistic activity of the flavonoid aglycones apigenin and cirsimaritin in HepG2 and HT29\u2005cell lines. The present study contributes to the evidence of the traditional uses of <jats:italic>Stachys<\/jats:italic> spp. and its bioactive constituents, justifying the ethnopharmacological use as an anti\u2010inflammatory plant genus.<\/jats:p>","DOI":"10.1002\/cbdv.202400457","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T16:35:31Z","timestamp":1726850131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phytochemical Study of <i>Stachys iva<\/i> Griseb. and <i>In Vitro<\/i> Evaluation of AhR Transcriptional Activity"],"prefix":"10.1002","volume":"21","author":[{"given":"Maria","family":"Anagnostou","sequence":"first","affiliation":[{"name":"Section of Pharmacognosy &amp; Chemistry of Natural Products Department of Pharmacy School of Health Sciences National and Kapodistrian University of Athens  Panepistimiopolis, Zografou 15771 Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina\u2010Michaela","family":"Tomou","sequence":"additional","affiliation":[{"name":"Section of Pharmacognosy &amp; Chemistry of Natural Products Department of Pharmacy School of Health Sciences National and Kapodistrian University of Athens  Panepistimiopolis, Zografou 15771 Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Goya\u2010Jorge","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy University of Valencia  Av. 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