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The escalating prevalence of male infertility in the contemporary era across the globe can be largely attributed to environmental pollution, which is the common etiological factor due to the ubiquitous presence of the environmental contaminants. Bisphenol A is recognized as an endocrine\u2010disrupting chemical that has adverse effects on both male and female reproductive systems. On the other hand, numerous studies have demonstrated that <jats:italic>Panax ginseng<\/jats:italic> possessed the potential to improve male infertility parameters; promote spermatogenesis, recover the quality and motility of sperm and enhance testicular functions as it acted as a natural androgen supplement. The objective of this review is to offer a summary of the findings obtained from the current research data on the insult of bisphenol A (BPA) on male infertility and its supposed mode of action, as well as shed light on the potent ameliorative role of <jats:italic>Panax ginseng<\/jats:italic> extract, with a special focus on the mechanism behind its action. This review delivers a clear understanding of BPA mechanism of action on male infertility and the presumed risks deriving from its exposure. Also, this review provides evidence for the functional role of <jats:italic>Panax ginseng<\/jats:italic> extract in restoring male fertility.<\/jats:p>","DOI":"10.1002\/cbdv.202400480","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T08:31:53Z","timestamp":1717144313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mechanistic Insights into Bisphenol A\u2010Mediated Male Infertility: Potential Role of <i>Panax Ginseng<\/i> Extract"],"prefix":"10.1002","volume":"21","author":[{"given":"Basma I.","family":"El\u2010Shimi","sequence":"first","affiliation":[{"name":"Chemistry Department Faculty of Sciences Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafat M.","family":"Mohareb","sequence":"additional","affiliation":[{"name":"Chemistry Department Faculty of Sciences Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa H.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Hormones Department Medical Research and Clinical Studies Institute National Research Centre  Giza Egypt"},{"name":"Stem Cell Lab. 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