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Antioxidant activity was tested using DPPH and ABTS scavenging assays, reducing power, phenanthroline and silver nanoparticle (SNP) assays. The anti\u2013Alzheimer's activity of extracts was also performed\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    and\n                    <jats:italic>in silico<\/jats:italic>\n                    . Phytochemical analysis highlighted the richness ofthe extracts in terms of coumarins, terpenoids and quercetin. The quantitative determination of total polyphenols and flavonoids showed that the highest amounts occurredinthe dichloromethane (DCME) and methanolic (MeOH) extracts. The antioxidant activities indicated a moderate potential. Compared with galantamine, DCME had a significantly greater anti\u2013Alzheimer effect on BChE(CI\n                    <jats:sub>50<\/jats:sub>\n                    =9.14\u00b11.74\u2005\u03bcg\/ml and 34.75\u00b11.99\u2005\u03bcg\/ml respectively). An\n                    <jats:italic>in silico<\/jats:italic>\n                    study of anti\u2013Alzheimer activity revealed a significant effect of quercetin(\u221230,13\u2005KJ\/mol). Conclusion: This study demonstrated the richness of the phytochemical components of\n                    <jats:italic>seseli tortuosum<\/jats:italic>\n                    ,which are responsible for several biological properties, mainly their anti\u2010Alzheimer potential.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202400482","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T15:13:52Z","timestamp":1726586032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Phytochemical Characterization and Assessment of Antioxidant and Anti\u2010Alzheimer Effects of Algerian\n                    <i>Seseli Tortuosum<\/i>"],"prefix":"10.1002","volume":"22","author":[{"given":"Abdelkader","family":"Slimani","sequence":"first","affiliation":[{"name":"Unit of the Valorization of Natural Resources BioactiveMolecules and Physicochemical and Biological Analysis Faculty of Exact Sciences University Constantine 1  Constantine 25000 Algeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wail","family":"Akkal","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry Faculty of Natural and Life Sciences University Constantine 1  Constantine 25000 Algeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Acheraf Benmekhbi","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry Faculty of Natural and Life Sciences University Constantine 1  Constantine 25000 Algeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Mosbah","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry Faculty of Natural and Life Sciences University Constantine 1  Constantine 25000 Algeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz","family":"Selim Cakmak","sequence":"additional","affiliation":[{"name":"Aksaray University, Faculty of Science and Letters, Department of Biotechnology and Molecular Biology, 68100, Aksaray, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostefa","family":"Lefahal","sequence":"additional","affiliation":[{"name":"Unit of the Valorization of Natural Resources BioactiveMolecules and Physicochemical and Biological Analysis Faculty of Exact Sciences University Constantine 1  Constantine 25000 Algeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlem","family":"Bousetla","sequence":"additional","affiliation":[{"name":"Unit of the Valorization of Natural Resources BioactiveMolecules and Physicochemical and Biological Analysis Faculty of Exact Sciences University Constantine 1  Constantine 25000 Algeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El Hassen","family":"Mokrani","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry Faculty of Natural and Life Sciences University Constantine 1  Constantine 25000 Algeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chawki","family":"Bensouici","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie, Biotechnologie et Division Sant\u00e9 Centre de Recherche en Biotechnologie  25000 Constatine Algeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hocine","family":"Laouer","sequence":"additional","affiliation":[{"name":"Laboratory for the Valorization of Natural Biological Resources Ferhat Abbas University  Setif 19000 Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah","family":"Akkal","sequence":"additional","affiliation":[{"name":"Unit of the Valorization of Natural Resources BioactiveMolecules and Physicochemical and Biological Analysis Faculty of Exact Sciences University Constantine 1  Constantine 25000 Algeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Nieto","sequence":"additional","affiliation":[{"name":"Department of Food Technology Food Science and Nutrition Faculty of Veterinary Sciences Regional Campus of International Excellence Campus Mare Nostrum\u201d University of Murcia, Espinardo  30071 Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"issue":"4","key":"e_1_2_8_1_1","first-page":"177","volume":"10","author":"Ekor M.","year":"2014","journal-title":"Front. 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