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It required the application of four distinct variables: rotation speed (50, 75, and 100\u2005rpm), magnetic field (0.8, 1.2, and 1.6\u2005T), time interval (30, 60, and 90\u2005min), and temperature (45, 55, and 65\u2009\u00b0C). Numerous phytochemical categories were detected in the 81\u2005crude chloroform extracts of green sweet bell pepper seeds that were collected, according to phytochemical analysis. Nine extracts were discovered to be linked to the coumarin chemical class and to have the same two extraction parameters: a 90\u2010minute extraction duration and a 55\u2009\u00b0C extraction temperature. To enable their coumarin contents to be chemically separated and chromatographically purified, two of these extracts containing coumarin were chosen. Four new phytocoumarins have been identified and their molecular structures distinguished using FTIR spectra, <jats:sup>1<\/jats:sup>H\u2010NMR, <jats:sup>13<\/jats:sup>C\u2010NMR, and mass analysis. By using MTT probing, it was discovered that these phytocoumarins exhibited anticancer activities against eight malignant populations and reduced oxidative stress in human SH\u2010SY5Y populations. Similarly, the anti\u2010inflammatory and antidiabetic properties were determined using three and two associated enzymes, respectively. The results demonstrated that the extracted phytocoumarins have exceptional oxidative stress\u2010mitigating characteristics, ranging from 71.51 to 81.48\u2009%, when compared to a positive control. Furthermore, they showed excellent cytotoxicity against the test malignant populations (IC<jats:sub>50<\/jats:sub> values of 46.76\u201381.45\u2005\u03bcg\/ml). The isolates need to be taken into account as dual COX\u20102\/5\u2010LOX antagonists because they also showed a fascinating selective anti\u2010inflammatory effect. The phytocoumarins under investigation have selectivity indices that are higher than those of the standards used, suggesting that they may have the ability to selectively block the COX2 enzyme that induces harmful inflammation. Compared to the standards, the phytocoumarins have a higher ability to block the catalytic activity of 5\u2010LOX. This observation suggests that the phytocoumarins are powerful 5\u2010LOX agents. Finally, they had a modest antidiabetic impact when tested against two blood\u2010controlling enzymes. The authors came to the conclusion that the technique adopted is flexible and successful for extraction after modifying its components. Moreover, isolated phytocoumarins in general and <jats:bold>natural\u2010B1<\/jats:bold> in particular provide naturally derived solutions for oxidative stress and its associated diseases.<\/jats:p>","DOI":"10.1002\/cbdv.202400581","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T14:44:12Z","timestamp":1713192252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Unveiling the Biomedical Applications of Novel Coumarins Isolated From <i>Capsicum Annuum L<\/i>. 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