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The newly synthesized compounds <jats:bold>8a<\/jats:bold>\u2013<jats:bold>l<\/jats:bold> were screened for their invitro antioxidant and anti\u2010inflammatory activities by employing <jats:italic>Ascorbic acid<\/jats:italic> and <jats:italic>Diclofenac<\/jats:italic> as reference drugs respectively. The compound without any substituent on benzyl ring (<jats:bold>8a<\/jats:bold>), compound with \u2010Cl substituent in para position of benzyl ring <jats:bold>(8i)<\/jats:bold>, and compound with ethoxy substituent in para position of benzyl ring (<jats:bold>8k)<\/jats:bold> exhibited potent antioxidant and anti\u2010inflammatory activities with higher percentage of inhibition. To understand their binding affinities, molecular docking study of these three compounds performed against NADPH oxidase with presented outstanding docking scores and promising binding interactions like H\u2010bond and hydrophobic.<\/jats:p>","DOI":"10.1002\/cbdv.202400587","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T17:53:31Z","timestamp":1715190811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Synthesis of New Chroman\u20104\u2010one Based 1,2,3\u2010Triazole Analogues as Antioxidant and Anti\u2010Inflammatory Agents"],"prefix":"10.1002","volume":"21","author":[{"given":"Shankaraiah","family":"Ambala","sequence":"first","affiliation":[{"name":"Department of Chemistry Osmania University  Hyderabad 500007 Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6830-3671","authenticated-orcid":false,"given":"Vishnu","family":"Thumma","sequence":"additional","affiliation":[{"name":"Department of Sciences and Humanities Matrusri Engineering College  Hyderabad 500059 Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerabhadraiah","family":"Mallikanti","sequence":"additional","affiliation":[{"name":"Department of Chemistry Osmania University  Hyderabad 500007 Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineesha","family":"Bathini","sequence":"additional","affiliation":[{"name":"Department of Chemistry Osmania University  Hyderabad 500007 Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyothi","family":"K","sequence":"additional","affiliation":[{"name":"St. Marys College of Pharmacy, Secunderabad  Hyderabad 500025 Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5419-6868","authenticated-orcid":false,"given":"Jalapathi","family":"Pochampally","sequence":"additional","affiliation":[{"name":"Department of Chemistry Osmania University  Hyderabad 500007 Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/np9860300465"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)97532-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.6.1477"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2009.1251"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2012.01.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.279.6.G1148"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0505170"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.02.048"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113823"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2023.100987"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13738-021-02365-y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdc.2023.101034"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202204020"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10593-021-03000-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200502161"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756360903524304"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA04727F"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-013-0762-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.07.024"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201500051"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161206776873563"},{"key":"e_1_2_8_22_1","first-page":"305","volume":"20","author":"Sultana N.","year":"2007","journal-title":"Pak. 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