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This review gives an in\u2010depth examination of the various therapeutic approaches used to combat guinea worm disease. This study seeks to provide a current and evidence\u2010based summary of available treatment techniques by conducting an exhaustive examination of peer\u2010reviewed literature, medical databases, and official health organisation publications. The current review intends to contribute to the knowledge base and influence plans for guinea worm disease control and eradication by critically evaluating the success and obstacles associated with various treatment approaches through standard heterocyclic medications, herbal sources, phytochemicals, and nanomedicines. 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