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Herein, this study is designed to assess the antidiabetic activity of <jats:italic>Astragalus kurdicus<\/jats:italic> total (AKM: methanol extract, yield: 14.53\u2009%) and sub\u2010extracts (AKB: n\u2010butanol, AKC: chloroform, AKW: water, AKH: hexane extracts), utilizing a range of diabetes\u2010related <jats:italic>in\u2005vitro<\/jats:italic> methodologies, and to investigate the chemical composition of the plant. The highest astragaloside and saponin content was seen in AKB extract. Among the measured saponins, the abundance of Astragaloside\u2005IV (27.41\u2005\u03bcg\/mg in AKM) was the highest in high\u2010performance thin\u2010layer chromatography (HPTLC) analysis. Furthermore, flavonoid\u2010rich AKC was found to be mostly responsible for the high antioxidant activity. According to the results of the activity tests, AKW was the most active extract in protein tyrosine phosphatase 1\u2005B (PTP1B), dipeptidyl peptidase\u2005IV (DPP4), and \u03b1\u2010amylase inhibition tests (percent inhibitions are: 87.17\u2009%, 82.4\u2009%, and 91.49\u2009% respectively, at 1\u2005mg\/mL). AKM and AKW demonstrated the highest efficacy in stimulating the growth of prebiotic microorganisms and preventing the formation of advanced glycation end products (AGEs). Thus, for the first time, the antidiabetic activity of <jats:italic>A. kurdicus<\/jats:italic> was evaluated from various perspectives.<\/jats:p>","DOI":"10.1002\/cbdv.202400699","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T08:27:10Z","timestamp":1718094430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of Phytochemistry and Antidiabetic Potential of an <i>Astragalus<\/i> Species (<i>Astragalus kurdicus<\/i> Boiss.)"],"prefix":"10.1002","volume":"21","author":[{"given":"Kevser","family":"Ozdemir","sequence":"first","affiliation":[{"name":"Institute of Health Sciences Istanbul University  Fatih Istanbul 34116, Turkiye"},{"name":"Faculty of Pharmacy Department of Pharmacognosy F\u0131rat University  Merkez, Elazig 23200, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timur","family":"Hakan Barak","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmacognosy Acibadem Mehmet Ali Aydinlar University  Atasehir Istanbul 34755, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inci","family":"Kurt Celep","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmacognosy Acibadem Mehmet Ali Aydinlar University  Atasehir Istanbul 34755, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan","family":"Savasan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmaceutical Microbiology Acibadem Mehmet Ali Aydinlar University  Atasehir Istanbul 34755, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serpil","family":"Demirci Kay\u0131ran","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmaceutical Botany Cukurova University  Merkez Adana 01330, Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Eroglu Ozkan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmacognosy Istanbul University  Fatih Istanbul 34116 Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"e_1_2_13_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.08.001"},{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018818755019"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.5455\/jice.20161219011346"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2020.16.13"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2019.03.006"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(12)60067\u20137"},{"issue":"01","key":"e_1_2_13_8_1","first-page":"32","volume":"82","author":"Khangholi S.","year":"2016","journal-title":"Planta Med."},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35014-1"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154712"},{"key":"e_1_2_13_11_1","unstructured":"Diagnosis and management of type 2 diabetes (HEARTS\u2212D). 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