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The chemical composition was analyzed using GC\u2013MS and TLC techniques. The oral acute toxicity study was performed according to the WHO 2000 and the OECD 420 guidelines. Furthermore, anti\u2010diabetic activity was investigated using two doses of ASFEE (0.2 and 0.5\u2005g\/kg\/day BW, p.o.) compared with glibenclamide (5\u2005mg\/kg\/day, p.o.). A molecular docking investigation of the identified components with the PTPN9 enzyme was performed to figure out the proposed anti\u2010diabetic mechanism. GC\u2013MS analysis displayed the existence of 18 compounds; most\u00a0of the compounds\u00a0were fatty acids and their\u00a0esters, and phytosterols. Total phenolic and flavonoid contents were 42.00\u00b11.26\u2005mg GAE\/g DW and 22.21\u00b11.55\u2005mg QE\/g DW, respectively. The results of the <jats:italic>in\u2010vivo<\/jats:italic> toxicity study revealed the absence of noticeable signs of toxicity or mortality at various doses establishing the safety of the tested extract. The estimated LD<jats:sub>50<\/jats:sub> value was higher than 10\u2005g\/kg. Antidiabetic action exhibited a noticeable decline in fasting blood glucose (FBG) levels comparable to glibenclamide with no inducing intense hypoglycemia and considerable excess weight.<\/jats:p>","DOI":"10.1002\/cbdv.202400707","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T16:33:52Z","timestamp":1726504432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chemical Characterization, Evaluation of Acute Oral Toxicity, and Anti\u2010Diabetic Activity of <i>Aloe sabaea<\/i> Flowers Extract on Alloxan\u2010Induced Diabetic Rats"],"prefix":"10.1002","volume":"21","author":[{"given":"Salwa M.","family":"Raweh","sequence":"first","affiliation":[{"name":"Pharmacognosy Department University of Sana'a, Pharmacy College  Sanaa Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amina","family":"El\u2010Shaibany","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department University of Sana'a, Pharmacy College  Sanaa Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Al\u2010Mahbashi","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Clinical Toxicology College of Medicine Sana'a University  Sanaa Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed S.","family":"Abdelkhalek","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Department Faculty of Pharmacy Zagazig University  Zagazig 44519 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesreen M. 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