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The synthesized compounds were characterized by various spectroscopic analytical methods. The <jats:italic>in\u2010vitro<\/jats:italic> anti\u2010malarial investigations revealed that the complex CuL exhibited equipotency with quinine drug having IC<jats:sub>50<\/jats:sub> value 0.25\u2005\u03bcg\/mL. The compound L showed significant inhibition of bacterial spp. <jats:italic>viz. E. Coli<\/jats:italic>, <jats:italic>P. Aeruginosa<\/jats:italic>, and <jats:italic>S. Aureus<\/jats:italic> (MIC=12.5\u201350\u2005\u03bcg\/mL), while the compound CoL (MIC=12.5\u2005\u03bcg\/mL) exhibited potency against gram\u2010positive bacteria. In the <jats:italic>in\u2010vitro<\/jats:italic> anti\u2010inflammatory study, the compound CuL displayed moderate activity than other tested compounds. The compound CuL showed the highest anti\u2010malarial docking score with enzyme <jats:italic>pLDH<\/jats:italic> at \u22128.12\u2005Kcal\/mol. The DFT study also gives authentication of higher antimalarial activity of CuL due to high dipole moment. None of the potent compounds was found cytotoxic towards <jats:italic>vero cell<\/jats:italic> lines.<\/jats:p>","DOI":"10.1002\/cbdv.202400715","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T02:18:53Z","timestamp":1717381133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anti\u2010Malarial and Multi\u2010Bioactive Co (II), Cu (II) and Ni (II) Salen Complexes: Synthesis, Characterization and Computational Studies"],"prefix":"10.1002","volume":"21","author":[{"given":"Minakshee A.","family":"Todarwal","sequence":"first","affiliation":[{"name":"Department of Chemistry SNJB's KKHA Arts SMGL Commerce and SPHJ Science College  Chandwad 423101 India"},{"name":"School of Chemical Sciences KBC North Maharashtra University  Jalgaon 425001 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh S.","family":"Sancheti","sequence":"additional","affiliation":[{"name":"Department of Chemistry SNJB's KKHA Arts SMGL Commerce and SPHJ Science College  Chandwad 423101 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit R.","family":"Nikume","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences KBC North Maharashtra University  Jalgaon 425001 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harun M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry R. 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